Article Version 1 Preserved in Portico This version is not peer-reviewed
Membrane Potential: Any Diffusion?
Version 1 : Received: 10 February 2022 / Approved: 11 February 2022 / Online: 11 February 2022 (10:27:36 CET)
How to cite: Delalande, B.; Tamagawa, H.; Matveev, V. Membrane Potential: Any Diffusion?. Preprints 2022, 2022020160. https://doi.org/10.20944/preprints202202.0160.v1. Delalande, B.; Tamagawa, H.; Matveev, V. Membrane Potential: Any Diffusion?. Preprints 2022, 2022020160. https://doi.org/10.20944/preprints202202.0160.v1.
The generation and maintenance of membrane potential is a fundamental part of Membrane Pump Theory. One of the key points of this hypothesis is based on a natural or facilitated molecular diffusion through several types of ion channels and pumps like the Na/K ATPase. Chemistry, physics and especially electrochemistry, however, bring strong contradictions to this theoretical assumption. By respecting the principles of chemistry and electrostatics, it becomes obvious that this theoretical hypothesis cannot work. The ionic diffusion that would be at the origin of this potential cannot take place. Indeed, the topology and the forces involved definitively exclude the current model, which must absolutely be revised according to the current state of our knowledge and allow an advance in the understanding of the phenomena and open new research perspectives.
membrane pump theory; membrane potential; diffusion; Biophysics; Biology
LIFE SCIENCES, Biochemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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