Okpala, V.N.; Edet, M.M.; Ezejindu, D.N. The Effect of Avocado Seed Extract (Persea americana) on Carbide Induced Hepatoxicity in Adult Wistar Rats. Preprints2022, 2022020091. https://doi.org/10.20944/preprints202202.0091.v1
APA Style
Okpala, V.N., Edet, M.M., & Ezejindu, D.N. (2022). The Effect of Avocado Seed Extract (Persea americana) on Carbide Induced Hepatoxicity in Adult Wistar Rats. Preprints. https://doi.org/10.20944/preprints202202.0091.v1
Chicago/Turabian Style
Okpala, V.N., Mark Matthew Edet and Damian Nnabuihe Ezejindu. 2022 "The Effect of Avocado Seed Extract (Persea americana) on Carbide Induced Hepatoxicity in Adult Wistar Rats" Preprints. https://doi.org/10.20944/preprints202202.0091.v1
Abstract
Context: Persea Americana is reported to have medicinal value. Calcium Carbide (CaC2), a fruit-ripening agent, has been shown to be toxic to body organs. Objective: To determine the effect of avocado seed extract (ASE) on CaC2-induced hepatotoxicity in rats. Methodology: Four experimental groups, each of 5 adult wistar rats were fed respectively with normal diets (group A); 250mg/kg ASE (group B); 100mg/kg CaC2 (group C); combination of 100mg/kg CaC2 and 250mg/kg ASE – group D. Changes in the rats’ behaviours, body weights, and liver function were assessed over 21 days. Data were analyzed using SPSS. The cumulated rat weights, rat liver weights and serum liver enzyme levels for groups B, C, and D rats were compared to group A. Results: Abnormal behavior was most observed in group C rats. Rats in group A showed a significant increase in weight before and three weeks following administration of feeds while rats in groups B, C, and D showed significant decrease in weight – more marked in group C rats. Only the mean liver weights of rats in group C showed significant decrease compared to that in group A, p = 0.001. Similarly, only the cumulated liver enzyme levels of rats in group C demonstrated significant increase when compared to group A rats - indicating hepatotoxicity. Conclusion In this study, hepatotoxicity occurred in CaC2-administered rats. However, the combination of CaC2 and ASE showed no liver toxicity indicating a mitigating effect of ASE to CaC2-induced hepatotoxicity.
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
