Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

User-View on Organ-on-a-Chip Technology

Version 1 : Received: 1 February 2022 / Approved: 2 February 2022 / Online: 2 February 2022 (12:20:19 CET)

A peer-reviewed article of this Preprint also exists.

Busek, M.; Aizenshtadt, A.; Amirola-Martinez, M.; Delon, L.; Krauss, S. Academic User View: Organ-on-a-Chip Technology. Biosensors, 2022, 12, 126. https://doi.org/10.3390/bios12020126. Busek, M.; Aizenshtadt, A.; Amirola-Martinez, M.; Delon, L.; Krauss, S. Academic User View: Organ-on-a-Chip Technology. Biosensors, 2022, 12, 126. https://doi.org/10.3390/bios12020126.

Abstract

Organ-on-a-Chip (OoC) systems bring together cell biology, engineering, and material science for creating systems that recapitulate the in vivo microenvironment of tissues and organs. The versatility of OoC systems enables in vitro models for studying physiological processes, drug development, and testing in both academia and industry. This paper evaluates current platforms from the end-user perspective, elaborating on usability, complexity, and robustness. We surveyed 165 peers in over 30 countries and grouped the responses according to preliminary knowledge and the source of the OoC systems that are used. The survey clearly shows that current commercial OoC platforms provide a substantial level of robustness and usability - which is also indicated by an increasing adaptation of the pharmaceutical industry but a lack of complexity can challenge their use as a predictive platform. Self-made systems on the other hand are less robust and standardized but provide the opportunity to develop customized and more complex models which are often needed for human disease modeling. This review serves as a guide for researchers in the OoC field and encourages the development of next-generation OoCs.

Keywords

Organ-on-a-Chip (OoC); Micro-physiological systems (MPS); survey; usability; limitations; disease models; drug testing

Subject

Engineering, Bioengineering

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