Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Potential of Methocinnamox to Treat Opioid Misuse

Version 1 : Received: 30 January 2022 / Approved: 31 January 2022 / Online: 31 January 2022 (11:48:27 CET)

A peer-reviewed article of this Preprint also exists.

Jordan, C.G.; Kennalley, A.L.; Roberts, A.L.; Nemes, K.M.; Dolma, T.; Piper, B.J. The Potential of Methocinnamox as a Future Treatment for Opioid Use Disorder: A Narrative Review. Pharmacy 2022, 10, 48. https://doi.org/10.3390/pharmacy10030048 Jordan, C.G.; Kennalley, A.L.; Roberts, A.L.; Nemes, K.M.; Dolma, T.; Piper, B.J. The Potential of Methocinnamox as a Future Treatment for Opioid Use Disorder: A Narrative Review. Pharmacy 2022, 10, 48. https://doi.org/10.3390/pharmacy10030048

Journal reference: Pharmacy 2022, 10, 48
DOI: 10.3390/pharmacy10030048

Abstract

The opioid epidemic is an ongoing public health crisis, and the United States health system is overwhelmed with increasing numbers of opioid-related overdoses. Methocinnamox (MCAM) is a novel mu-opioid receptor antagonist with an extended duration of action and potential to reduce the burden of the opioid epidemic through overdose rescue and could treat opioid use disorder (OUD) long-term. We compared the efficacy and effects of MCAM to the current treatments available to treat OUD including naloxone, naltrexone, methadone, and buprenorphine which have their own limitations including short duration of action, patient non-compliance, and diversion. A literature review was conducted using PubMed and Google Scholar databases covering the history of the opioid epidemic, pain receptors, current OUD treatments and the novel drug MCAM. MCAM could potentially be used as both a rescue and long-term treatment for opioid misuse. This is due to its pseudo-irreversible antagonism of the mu opioid receptor, abnormally long duration of action of nearly two weeks, and the possibility of using kappa or delta opioid receptor agonists for pain management during OUD treatment. MCAM’s novel pharmacokinetic and pharmacodynamic properties open a new avenue for treating the opioid crisis.

Keywords

methocinnamox; opioid; naloxone; naltrexone; methadone; buprenorphine; overdose; treatment; receptors; addiction

Subject

MEDICINE & PHARMACOLOGY, Pharmacology & Toxicology

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