Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Identification of Novel Multi-Omics Expression Landscapes and Meta-Analysis of Landscape-Based Competitive Endogenous RNA Networks in ALDH+ Lung Adenocarcinoma Stem Cells

Version 1 : Received: 17 January 2022 / Approved: 20 January 2022 / Online: 20 January 2022 (07:49:16 CET)
Version 2 : Received: 16 May 2022 / Approved: 16 May 2022 / Online: 16 May 2022 (10:56:02 CEST)
Version 3 : Received: 4 August 2022 / Approved: 4 August 2022 / Online: 4 August 2022 (16:29:49 CEST)

How to cite: Yang, W.; Liang, Y.; Zheng, Y.Y.; Luo, H.T.; Yang, X.F.; Li, F.R. Identification of Novel Multi-Omics Expression Landscapes and Meta-Analysis of Landscape-Based Competitive Endogenous RNA Networks in ALDH+ Lung Adenocarcinoma Stem Cells. Preprints 2022, 2022010286 (doi: 10.20944/preprints202201.0286.v1). Yang, W.; Liang, Y.; Zheng, Y.Y.; Luo, H.T.; Yang, X.F.; Li, F.R. Identification of Novel Multi-Omics Expression Landscapes and Meta-Analysis of Landscape-Based Competitive Endogenous RNA Networks in ALDH+ Lung Adenocarcinoma Stem Cells. Preprints 2022, 2022010286 (doi: 10.20944/preprints202201.0286.v1).

Abstract

ALHD+ H1975 lung adenocarcinoma stem cells(LSCs), confirmed to be found in LUAD, is one rare subset within lung adenocarcinoma(LUAD) cancer cells. They could self-renew, drive tumor initiation, growth, metastasis, and recurrence, and are also considered to be the main cause of poor prognosis because of their intrinsic resistance to drug and chemotherapy, which prompts them to be a promising target for LUAD therapy. NcRNAs, including miRNAs, lncRNAs, circRNAs are thought to exert many significant regulatory functions in the development of LUAD. However, systematic and comprehensive molecular profiling on ncRNAs and messenger RNAs(mRNAs) between LSCs and ALDH- H1975 lung adenocarcinoma tumor cells(LTCs) is insufficient. Therefore, by using stringent bio-informatics pipelines, we identified a set of novel ncRNAs including miRNAs, lncRNAs, circRNAs, and obtained differentially expressed landscapes on ncRNAs and mRNAs. Through further meta-analysis with those landscapes subsequently, we constructed novel competitive endogenous RNA(ceRNA) networks to excavate the potential molecular mechanisms that regulate the hallmarks of LSCs and LTCs. Herein, these results summarize novel ncRNAs and the fundamental roles of differentially expressed ncRNAs that have been implicated in LSCs and LTCs behaviors. It also provides a more comprehensive resource for the futural identification of diagnostic, therapeutic, and prognostic biomarkers in LUAD.

Keywords

novel ncRNAs; DE landscape; LSCs and LTCs; LncRNA; MiRNA; CircRNA; ceRNA networks; molecular mechanism

Subject

MEDICINE & PHARMACOLOGY, Oncology & Oncogenics

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