Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Roles of Proliferation and Angiogenesis in Locally Aggressive Biologic Behavior of Ameloblastoma versus Ameloblastic Fibroma

Version 1 : Received: 8 January 2022 / Approved: 12 January 2022 / Online: 12 January 2022 (08:20:26 CET)

A peer-reviewed article of this Preprint also exists.

Ibrahim, A.; Alqalshy, E.; Abdel-Hafiz, A.A.-S.; El-Rahman, K.A.; Alazzazi, M. Roles of Proliferation and Angiogenesis in Locally Aggressive Biologic Behavior of Ameloblastoma versus Ameloblastic Fibroma. Diagnostics 2022, 12, 392. Ibrahim, A.; Alqalshy, E.; Abdel-Hafiz, A.A.-S.; El-Rahman, K.A.; Alazzazi, M. Roles of Proliferation and Angiogenesis in Locally Aggressive Biologic Behavior of Ameloblastoma versus Ameloblastic Fibroma. Diagnostics 2022, 12, 392.

Journal reference: Diagnostics 2022, 12, 392
DOI: 10.3390/diagnostics12020392

Abstract

Background: The present study was carried out to evaluate the roles of proliferation and angiogenesis in locally aggressive biologic behavior of ameloblastoma versus ameloblastic fibroma; Methods: 30 formalin-fixed paraffin embedded blocks (15 cases of ameloblastoma & 15 cases of ameloblastic fibroma) were used. To evaluate the proliferation, the tissue sections were stained with AgNORs stain. CD105 was used as immunohistochemical marker of angiogenesis. Quantitative evaluations of AgNORs were performed. The mean vascular density was evaluated as a measure for CD105 protein expression by using image analyzer computer system; Results: The mean number of AgNORs dots per nucleus was significantly higher in ameloblastoma as compared to ameloblastic fibroma. Also, the protein level of CD105 showed positive expression and wide distribution that the mean vascular density was significantly higher in ameloblastoma as compared to ameloblastic fibroma; Conclusion: Quantitative evaluation of AgNORs stain & the mean vascular density utilizing CD105 protein expression may reflect a higher proliferative activity and a more locally aggressive biologic behavior of ameloblastoma when compared to ameloblastic fibroma, that other factors may be involved in biologic behavior of ameloblastic fibroma.

Keywords

Proliferation; Angiogenesis; Biologic Behavior; Ameloblastoma; Ameloblastic Fibroma

Subject

MEDICINE & PHARMACOLOGY, Dentistry

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