Mora-Janiszewska, O.; Faryniak-Zuzak, A.; Darmochwał-Kolarz, D. Epigenetic Links between Microbiota and Gestational Diabetes. Int. J. Mol. Sci.2022, 23, 1831.
Mora-Janiszewska, O.; Faryniak-Zuzak, A.; Darmochwał-Kolarz, D. Epigenetic Links between Microbiota and Gestational Diabetes. Int. J. Mol. Sci. 2022, 23, 1831.
Mora-Janiszewska, O.; Faryniak-Zuzak, A.; Darmochwał-Kolarz, D. Epigenetic Links between Microbiota and Gestational Diabetes. Int. J. Mol. Sci.2022, 23, 1831.
Mora-Janiszewska, O.; Faryniak-Zuzak, A.; Darmochwał-Kolarz, D. Epigenetic Links between Microbiota and Gestational Diabetes. Int. J. Mol. Sci. 2022, 23, 1831.
Abstract
Gestational diabetes (GDM) is considered a significant and increasing problem worldwide. The growing body of evidence points out that a hostile intrauterine environment in mothers with GDM via epigenetic mechanisms induces "diabetogenic" and "obesogenic" changes in an offspring's DNA. This sets in motion a vicious intergenerational cycle of metabolic diseases gradually deteriorating the health of the human population. One of the most important players in this process seems to be altered microbiota/microbiome.
There is a chance that the identification of specific epigenetic marks may provide a key for future diagnostic, prognostic and therapeutic solutions/measures in the field of person-alized medicine. Given the reversibility of most epigenetic changes, an opportunity arises to improve the long-term health of the human population/race.
In this manuscript, we aim to summarize available data on epigenetic changes among women suffering from GDM and their progeny in association with changes in microbiome.
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
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