Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Epigenetic Issues. The Link Between Microbiota and Gestational Diabetes.

Version 1 : Received: 31 December 2021 / Approved: 6 January 2022 / Online: 6 January 2022 (10:30:40 CET)

How to cite: Mora-Janiszewska, O.; Faryniak-Zuzak, A.; Darmochwał-Kolarz, D. Epigenetic Issues. The Link Between Microbiota and Gestational Diabetes.. Preprints 2022, 2022010069 (doi: 10.20944/preprints202201.0069.v1). Mora-Janiszewska, O.; Faryniak-Zuzak, A.; Darmochwał-Kolarz, D. Epigenetic Issues. The Link Between Microbiota and Gestational Diabetes.. Preprints 2022, 2022010069 (doi: 10.20944/preprints202201.0069.v1).

Abstract

Gestational diabetes (GDM) is considered a significant and increasing problem worldwide. The growing body of evidence points out that a hostile intrauterine environment in mothers with GDM via epigenetic mechanisms induces "diabetogenic" and "obesogenic" changes in an offspring's DNA. This sets in motion a vicious intergenerational cycle of metabolic diseases gradually deteriorating the health of the human population. One of the most important players in this process seems to be altered microbiota/microbiome. There is a chance that the identification of specific epigenetic marks may provide a key for future diagnostic, prognostic and therapeutic solutions/measures in the field of person-alized medicine. Given the reversibility of most epigenetic changes, an opportunity arises to improve the long-term health of the human population/race. In this manuscript, we aim to summarize available data on epigenetic changes among women suffering from GDM and their progeny in association with changes in microbiome.

Keywords

gestational diabetes mellitus; epigenetics; microbiota

Subject

MEDICINE & PHARMACOLOGY, Obstetrics & Gynaecology

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