Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Broad-spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effect

Coralia Fabiola Cuadrado
* ,
Antonio Díaz-Barrios
ORCID logo ,
Kleber Orlando Campana
,
Eric Cardona Romani
,
Francisco Javier Quiroz
,
Stefania Nardecchia
,
Alexis Debut
ORCID logo ,
Karla Vizuete
,
Dario Niebieskikwiat
,
Camilo Ernesto Ávila
,
Mateo Alejandro Salazar
,
Cristina Cecibel Garzón-Romero
ORCID logo ,
Ailín Amira Blasco-Zúñiga
ORCID logo ,
Miryan Rosita Rivera
,
María Paulina Romero
ORCID logo
Version 1 : Received: 31 December 2021 / Approved: 5 January 2022 / Online: 5 January 2022 (12:02:34 CET)

A peer-reviewed article of this Preprint also exists.

Cuadrado, C.F.; Díaz-Barrios, A.; Campaña, K.O.; Romani, E.C.; Quiroz, F.; Nardecchia, S.; Debut, A.; Vizuete, K.; Niebieskikwiat, D.; Ávila, C.E.; Salazar, M.A.; Garzón-Romero, C.; Blasco-Zúñiga, A.; Rivera, M.R.; Romero, M.P. Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects. Pharmaceutics 2022, 14, 705. Cuadrado, C.F.; Díaz-Barrios, A.; Campaña, K.O.; Romani, E.C.; Quiroz, F.; Nardecchia, S.; Debut, A.; Vizuete, K.; Niebieskikwiat, D.; Ávila, C.E.; Salazar, M.A.; Garzón-Romero, C.; Blasco-Zúñiga, A.; Rivera, M.R.; Romero, M.P. Broad-Spectrum Antimicrobial ZnMintPc Encapsulated in Magnetic-Nanocomposites with Graphene Oxide/MWCNTs Based on Bimodal Action of Photodynamic and Photothermal Effects. Pharmaceutics 2022, 14, 705.

Abstract

Microbial diseases have been declared one of the main threats to humanity, which is why, in recent years, great interest has been generated in the development of nanocomposites with antimicrobial capacity. In the present work, two magnetic nanocomposites, based on Graphene Oxide (GO) and Multiwall Carbon Nanotubes (MWCNTs) were studied. The synthesis of these magnetic nanocomposites consisted of three phases: first, the synthesis of Iron Magnetic Nanoparticles (MNPs) was carried out in the presence of MWCNTs and GO using the Co-precipitation method. The second phase consisted of the adsorption of photosensitizer menthol-Zinc phthalocyanine (ZnMintPc) into MWCNTs and GO, and the third phase was the encapsulation in poly (N-vinylcaprolactam-co-poly(ethylene glycol diacrylate)) poly (VCL-co-PEGDA) polymer VCL/PEGDA a biocompatible hydrogel, in order to obtain the magnetic nanocomposites: VCL/PEGDA-MNPs-MWCNTs-ZnMintPc and VCL/PEGDA-MNPs-GO-ZnMintPc. In vitro studies were carried out using Escherichia coli and Staphylococcus aureus bacteria and the Candida albicans yeast based on the PTT/PDT effect. This research describes the optical, morphological, magnetic and photophysical characterizations of nanocomposites and their application as antimicrobial agents. It was evaluated the antimicrobial effect of magnetics nanocomposites based on the Photodynamic/Photothermal (PDT/PTT) effect; for this purpose, doses of 65 mW cm-2 at 630 nm of light were used. The VCL/PEGDA-MNPs-GO-ZnMintPc nanocomposite was able to eliminate colonies of E. coli and S. aureus, while VCL/PEGDA-MNPs-MWCNTs-ZnMintPc nanocomposite was able to eliminate the three types of microorganisms; consequently, the latter is considered a broad-spectrum of antimicrobial agent in PDT and PTT.

Keywords

Antimicrobial nanomaterials; Carbon Nanotubes; Graphene; Magnetic Nanoparticles; hydrogel; Photodynamic Therapy; Photothermal Therapy; Nanocarrier

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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