Version 1
: Received: 24 December 2021 / Approved: 27 December 2021 / Online: 27 December 2021 (10:31:10 CET)
Version 2
: Received: 27 December 2021 / Approved: 28 December 2021 / Online: 28 December 2021 (10:28:50 CET)
Version 3
: Received: 20 May 2022 / Approved: 23 May 2022 / Online: 23 May 2022 (11:10:00 CEST)
Nichani, K.; Uhlig, S.; Stoyke, M.; Kemmlein, S.; Ulberth, F.; Haase, I.; Döring, M.; Walch, S. G.; Gowik, P. Essential Terminology and Considerations for Validation of Non-Targeted Methods. Food Chemistry: X, 2023, 17, 100538. https://doi.org/10.1016/j.fochx.2022.100538.
Nichani, K.; Uhlig, S.; Stoyke, M.; Kemmlein, S.; Ulberth, F.; Haase, I.; Döring, M.; Walch, S. G.; Gowik, P. Essential Terminology and Considerations for Validation of Non-Targeted Methods. Food Chemistry: X, 2023, 17, 100538. https://doi.org/10.1016/j.fochx.2022.100538.
Nichani, K.; Uhlig, S.; Stoyke, M.; Kemmlein, S.; Ulberth, F.; Haase, I.; Döring, M.; Walch, S. G.; Gowik, P. Essential Terminology and Considerations for Validation of Non-Targeted Methods. Food Chemistry: X, 2023, 17, 100538. https://doi.org/10.1016/j.fochx.2022.100538.
Nichani, K.; Uhlig, S.; Stoyke, M.; Kemmlein, S.; Ulberth, F.; Haase, I.; Döring, M.; Walch, S. G.; Gowik, P. Essential Terminology and Considerations for Validation of Non-Targeted Methods. Food Chemistry: X, 2023, 17, 100538. https://doi.org/10.1016/j.fochx.2022.100538.
Abstract
Through its suggestive name, non-targeted methods (NTMs) do not aim at a predefined "needle in the haystack". Instead, they exploit all the constituents of the haystack. This new form of analytical methods is increasingly finding applications in food and feed testing. However, the concepts, terms, and considerations related to this burgeoning field of analytical testing needs to be propagated for the benefit of ones associated in academic research, commercial development, and official control. This paper addresses the frequently asked questions around notations and terminologies surrounding NTMs. The widespread development and adoption of these methods also necessitates the need to develop approaches to NTM validation, i.e., evaluating the performance characteristics of a method to determine if it is fit-for-purpose. This work aims to provide a roadmap to approaching NTM validation. In doing so, the paper deliberates on the different considerations that influence the approach to validation and provides suggestions thereof.
Chemistry and Materials Science, Analytical Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Commenter: Kapil Nichani
Commenter's Conflict of Interests: Author