Version 1
: Received: 22 December 2021 / Approved: 24 December 2021 / Online: 24 December 2021 (10:59:10 CET)
Version 2
: Received: 24 December 2021 / Approved: 27 December 2021 / Online: 27 December 2021 (15:48:53 CET)
How to cite:
Berliner, A.; Lipsky, I.; Ho, D.; Hilzinger, J.; Vengerova, G.; Makrygiorgos, G.; McNulty, M.; Yates, K.; Averesch, N.; Cockell, C.; Wallentine, T.; Seefeldt, L.; Criddle, C.; Nandi, S.; McDonald, K.; Menezes, A.; Mesbah, A.; Arkin, A. Space Bioprocess Engineering on the Horizon. Preprints2021, 2021120401 (doi: 10.20944/preprints202112.0401.v2).
Berliner, A.; Lipsky, I.; Ho, D.; Hilzinger, J.; Vengerova, G.; Makrygiorgos, G.; McNulty, M.; Yates, K.; Averesch, N.; Cockell, C.; Wallentine, T.; Seefeldt, L.; Criddle, C.; Nandi, S.; McDonald, K.; Menezes, A.; Mesbah, A.; Arkin, A. Space Bioprocess Engineering on the Horizon. Preprints 2021, 2021120401 (doi: 10.20944/preprints202112.0401.v2).
Cite as:
Berliner, A.; Lipsky, I.; Ho, D.; Hilzinger, J.; Vengerova, G.; Makrygiorgos, G.; McNulty, M.; Yates, K.; Averesch, N.; Cockell, C.; Wallentine, T.; Seefeldt, L.; Criddle, C.; Nandi, S.; McDonald, K.; Menezes, A.; Mesbah, A.; Arkin, A. Space Bioprocess Engineering on the Horizon. Preprints2021, 2021120401 (doi: 10.20944/preprints202112.0401.v2).
Berliner, A.; Lipsky, I.; Ho, D.; Hilzinger, J.; Vengerova, G.; Makrygiorgos, G.; McNulty, M.; Yates, K.; Averesch, N.; Cockell, C.; Wallentine, T.; Seefeldt, L.; Criddle, C.; Nandi, S.; McDonald, K.; Menezes, A.; Mesbah, A.; Arkin, A. Space Bioprocess Engineering on the Horizon. Preprints 2021, 2021120401 (doi: 10.20944/preprints202112.0401.v2).
Abstract
Reinvigorated public interest in human space exploration has led to the need to address the science and engineering challenges described by NASA's Space Technology Grand Challenges (STGCs) for expanding the human presence in space. Here we define Space Bioprocess Engineering (SBE) as a multi-disciplinary approach to design, realize, and manage a biologically-driven space mission as it relates to addressing the STGCs for advancing technologies to support the nutritional, medical, and incidental material requirements that will sustain astronauts against the harsh conditions of interplanetary transit and habitation offworld. SBE combines synthetic biology and bioprocess engineering under extreme constraints to enable and sustain a biological presence in space. Here we argue that SBE is a critical strategic area enabling long-term human space exploration; specify the metrics and methods that guide SBE technology life-cycle and development; map an approach by which SBE technologies are matured on offworld testing platforms; and suggest a means to train the next generation spacefaring workforce on the SBE advantages and capabilities. In doing so, we outline aspects of the upcoming technical and policy hurdles to support space biomanufacturing and biotechnology. We outline a perspective marriage between space-based performance metrics and the synthetic biology Design-Build-Test-Learn cycle as they relate to advancing the readiness of SBE technologies. We call for a concerted effort to ensure the timely development of SBE to support long-term crewed missions using mission plans that are currently on the horizon.
Keywords
space systems bioengineering; biomanufacturing; space bioprocess engineering; biotransformation human exploration; in situ resource utilization; life support systems; biomanufacturing; space policy
Subject
ENGINEERING, Biomedical & Chemical Engineering
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Commenter: Aaron Berliner
Commenter's Conflict of Interests: Author