Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Genetic Risks and Demographic History of Indigenous Goats of Mongolia Revealed by SNP Genotyping

Version 1 : Received: 13 December 2021 / Approved: 14 December 2021 / Online: 14 December 2021 (13:25:27 CET)

A peer-reviewed article of this Preprint also exists.

Mukhina, V.; Svishcheva, G.; Voronkova, V.; Stolpovsky, Y.; Piskunov, A. Genetic Diversity, Population Structure and Phylogeny of Indigenous Goats of Mongolia Revealed by SNP Genotyping. Animals 2022, 12, 221. Mukhina, V.; Svishcheva, G.; Voronkova, V.; Stolpovsky, Y.; Piskunov, A. Genetic Diversity, Population Structure and Phylogeny of Indigenous Goats of Mongolia Revealed by SNP Genotyping. Animals 2022, 12, 221.

Journal reference: Animals 2022, 12, 221
DOI: 10.3390/ani12030221

Abstract

Recent climatic disasters (dzudzs) and uncontrolled massive breeding endangered valuable ge-netic resources of Mongolian goats labored by five thousand years of evolution in extremes of Al-tai mountains and Gobi deserts. Meanwhile, Mongolian goats has never been characterized by genomic data. We used Illumina Goat SNP50 to investigate phylogenic relationships and genetic risks in 5 local Mongolian populations: Erchim (N=37) from geographically remote Darkhat Valley in the northern mountains, Ulgii Red (N=35) and Dorgon (N=28) from the western mountain region, Buural (N=34) from the western steppe and mountain areas and Gobi Gurvan Saikhan (N=33) from semi-arid steppe area in the South Gobi region. ROH analyses, estimated populations sizes and Fst values showed South Gobi and Darkhat Valley goats to be of a high risk of inbreed-ing that however appear to be of distinct origin (artificial selection vs geographical isolation). In-dices of genetic differentiations between Mongolian goats were relatively low compared to Euro-pean breeds. Meanwhile, we suggest direct comparison is not fully appropriate given that Mongo-lian breeds were not subjected to intense selection. Darkhat Valley goats were clearly differentiat-ed from other Mongolian breeds according to various types of analyses. Phylogenetic relationships within XXX breeds of the rest of the world plotted Mongolian goats between some Russian (Altai, Orenburg) and Chinese populations (Nanjiang and Qinggeli). Thus, present study (i) highlights demographic history Mongolian goats and (ii)provides unified SNP-data called for support deci-sions in conservational genetics. Finally, our work (iii) raises a question of how exactly these data should be compared to make objective choices.

Keywords

SNP; Mongolian goats; conservational genetics; genotyping

Subject

LIFE SCIENCES, Genetics

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