Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Solid Tumor Microenvironment - Breaking The Barrier For T Cells

Version 1 : Received: 11 December 2021 / Approved: 13 December 2021 / Online: 13 December 2021 (16:29:09 CET)
Version 2 : Received: 19 March 2022 / Approved: 21 March 2022 / Online: 21 March 2022 (10:57:52 CET)

A peer-reviewed article of this Preprint also exists.

Journal reference: BioEssays 2022, 44
DOI: 10.1002/bies.202100285


The tumor microenvironment plays a pivotal role in the behavior and development of solid tumors as well as shaping the immune response against them. As the tumor cells proliferate, the space they occupy and their physical interactions with the surrounding tissue increases. The growing tumor tissue becomes a complex dynamic structure, containing connective tissue, vascular structures, and extracellular matrix that facilitates stimulation, oxygenation, and nutrition, necessary for its fast growth. Mechanical cues such as stiffness, solid stress, interstitial fluid pressure, matrix density, and microarchitecture influence cellular functions and ultimately tumor progression and metastasis. In this fight, our body is equipped with T cells as its spearhead against tumors. However, the altered biochemical and mechanical environment of the tumor niche affects T cell efficacy and leads to their exhaustion. Understanding the mechanobiological properties of the tumor microenvironment and their effects on T cells is key for developing novel adoptive tumor immunotherapies.


tumor microenvironment; immunology; mechanobiology


BIOLOGY, Anatomy & Morphology

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