Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Neisseria Mucosa Does Not Inhibit the Growth of Neisseria gonorrhoeae

Version 1 : Received: 18 November 2021 / Approved: 19 November 2021 / Online: 19 November 2021 (12:23:16 CET)

How to cite: Abdellati, S.; Laumen, J.; Gonzalez, N.; Manoharan-Basil, S.; Van Dijck, C.; De Baetselier, I.; Martiny, D.; De Block, T.; Kenyon, C. Neisseria Mucosa Does Not Inhibit the Growth of Neisseria gonorrhoeae. Preprints 2021, 2021110348 (doi: 10.20944/preprints202111.0348.v1). Abdellati, S.; Laumen, J.; Gonzalez, N.; Manoharan-Basil, S.; Van Dijck, C.; De Baetselier, I.; Martiny, D.; De Block, T.; Kenyon, C. Neisseria Mucosa Does Not Inhibit the Growth of Neisseria gonorrhoeae. Preprints 2021, 2021110348 (doi: 10.20944/preprints202111.0348.v1).

Abstract

Antibiotic-sparing treatments are required to prevent the further emergence of anti-microbial resistance in Neisseria gonorrhoeae. Commensal Neisseria species have previously been found to inhibit the growth of pathogenic Neisseria species. For example, a previous study found that 3 out of 5 historical isolates of Neisseria mucosa could inhibit the growth of N. gonorrhoeae. In this study, we used agar overlay assays to assess if 24 circulating and historical isolates of Neisseria mucosa could inhibit the growth of 28 circulating and historical isolates of N. gonorrhoeae. Although pitting around each colony of N. mucosa created an optical illusion of decreased growth of N. gonorrhoeae, we found no evidence of inhibition (n=24). In contrast, positive controls of Streptococcus pneumoniae and Escherichia coli demonstrated a strong inhibitory effect against the growth of N. gonorrhoeae.

Keywords

Agar over assay; bacterial inhibition; Neisseria gonorrhoeae; Neisseria mucosa

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