Correlation Between Vascular Inflammation Markers, Diastolic Dysfunction and Cardiovascular Risk in Patients with Takayasu Arteritis

Sebastiano Cicco; Vanessa Desantis; Antonio Vacca; Gerardo Cazzato; Antonio Giovanni Solimando; Anna Lisa Cirulli; Silvia Noviello; Cecilia Susca; Marcella Prete; Gabriele Brosolo; Cristiana Catena; Aurelia Lamanuzzi; Ilaria Saltarella; Maria Antonia Frassanito; Antonietta Cimmino; Giuseppe Ingravallo; Leonardo Resta; Roberto Ria; Monica Montagnani

doi:10.20944/preprints202111.0222.v1

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preprints.org > medicine and pharmacology > pathology and pathobiology > doi: 10.20944/preprints202111.0222.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Correlation Between Vascular Inflammation Markers, Diastolic Dysfunction and Cardiovascular Risk in Patients with Takayasu Arteritis

Antonio Giovanni Solimando

Maria Antonia Frassanito

^* ,

Version 1 : Received: 10 November 2021 / Approved: 12 November 2021 / Online: 12 November 2021 (13:40:14 CET)

How to cite: Cicco, S.; Desantis, V.; Vacca, A.; Cazzato, G.; Solimando, A.G.; Cirulli, A.L.; Noviello, S.; Susca, C.; Prete, M.; Brosolo, G.; Catena, C.; Lamanuzzi, A.; Saltarella, I.; Frassanito, M.A.; Cimmino, A.; Ingravallo, G.; Resta, L.; Ria, R.; Montagnani, M. Correlation Between Vascular Inflammation Markers, Diastolic Dysfunction and Cardiovascular Risk in Patients with Takayasu Arteritis. Preprints 2021, 2021110222. https://doi.org/10.20944/preprints202111.0222.v1 Cicco, S.; Desantis, V.; Vacca, A.; Cazzato, G.; Solimando, A.G.; Cirulli, A.L.; Noviello, S.; Susca, C.; Prete, M.; Brosolo, G.; Catena, C.; Lamanuzzi, A.; Saltarella, I.; Frassanito, M.A.; Cimmino, A.; Ingravallo, G.; Resta, L.; Ria, R.; Montagnani, M. Correlation Between Vascular Inflammation Markers, Diastolic Dysfunction and Cardiovascular Risk in Patients with Takayasu Arteritis. Preprints 2021, 2021110222. https://doi.org/10.20944/preprints202111.0222.v1

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MDPI and ACS Style

Cicco, S.; Desantis, V.; Vacca, A.; Cazzato, G.; Solimando, A.G.; Cirulli, A.L.; Noviello, S.; Susca, C.; Prete, M.; Brosolo, G.; Catena, C.; Lamanuzzi, A.; Saltarella, I.; Frassanito, M.A.; Cimmino, A.; Ingravallo, G.; Resta, L.; Ria, R.; Montagnani, M. Correlation Between Vascular Inflammation Markers, Diastolic Dysfunction and Cardiovascular Risk in Patients with Takayasu Arteritis. Preprints 2021, 2021110222. https://doi.org/10.20944/preprints202111.0222.v1

APA Style

Cicco, S., Desantis, V., Vacca, A., Cazzato, G., Solimando, A.G., Cirulli, A.L., Noviello, S., Susca, C., Prete, M., Brosolo, G., Catena, C., Lamanuzzi, A., Saltarella, I., Frassanito, M.A., Cimmino, A., Ingravallo, G., Resta, L., Ria, R., & Montagnani, M. (2021). Correlation Between Vascular Inflammation Markers, Diastolic Dysfunction and Cardiovascular Risk in Patients with Takayasu Arteritis. Preprints. https://doi.org/10.20944/preprints202111.0222.v1

Chicago/Turabian Style

Cicco, S., Roberto Ria and Monica Montagnani. 2021 "Correlation Between Vascular Inflammation Markers, Diastolic Dysfunction and Cardiovascular Risk in Patients with Takayasu Arteritis" Preprints. https://doi.org/10.20944/preprints202111.0222.v1

Abstract

Background: Takayasu Arteritis (TAK) increases vascular stiffness and arterial resistance. Hypertension and atherosclerosis lead to similar changes. We investigated possible differences in cardiovascular remodeling between these diseases and whether the differences are correlated with immune cell expression. Methods: Patients with active TAK arteritis were compared with age- and sex-matched hypertensive and atherosclerotic patients. In a subpopulation of TAK patients, Treg/Th17 cells were measured before (T0) and after 18 months (T18) of infliximab treatment. Echocardiogram, supraaortic Doppler ultrasound, and lymphocytogram were performed in all patients. Histological and immunohistochemical evaluation of the vessel wall was performed to compare the in vivo results. Results: TAK patients have increased aortic valve dysfunction and diastolic dysfunction. These data have been associated with uric acid levels. A significant increase in aortic stiffness was also noted and associated with peripheral T lymphocyte levels. CD3+CD4+ cell infiltrates were detected in the vessel wall samples of these patients. They had a lower mean percentage of Tregs at T0 than controls, but levels increased significantly at T18. Opposite results were found in Th17 cells. Finally, TAK patients were found to have an increased risk of atherosclerotic cardiovascular disease (ASCVD). Conclusion: Our data suggest that different pathogenic mechanisms of vessel damage, including atherosclerosis, underlie TAK patients compared with control subjects. The increased risk of ASCVD in TAK patients correlates directly with the degree of inflammatory cell infiltration in the vessel wall. Infliximab restores the normal frequency of Tregs/Th17 in TAK patients and allows a possible reduction of steroids and immunosuppressants.

Keywords

Takayasu arteritis; echocardiography; immune cell infiltration; vascular stiffness; T helper like cells; regulatory T lymphocytes

Subject

Medicine and Pharmacology, Pathology and Pathobiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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