Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Therapeutic Applications of Engineered Chimeric Antigen Receptors-T cell for Cancer Therapy

Version 1 : Received: 21 October 2021 / Approved: 25 October 2021 / Online: 25 October 2021 (15:48:05 CEST)

How to cite: Hussain, A. Therapeutic Applications of Engineered Chimeric Antigen Receptors-T cell for Cancer Therapy. Preprints 2021, 2021100368 (doi: 10.20944/preprints202110.0368.v1). Hussain, A. Therapeutic Applications of Engineered Chimeric Antigen Receptors-T cell for Cancer Therapy. Preprints 2021, 2021100368 (doi: 10.20944/preprints202110.0368.v1).

Abstract

Findings of new targeted treatments with adequate safety evaluations is essential for better cancer cures and mortality rates. Immunotherapy holds promise for patients with relapsed disease, with the ability to elicit long-term remissions. Emerging promising clinical results in B-cell malignancy using gene-altered T-lymphocytes uttering chimeric antigen receptors have sparked a lot of interest. This treatment could open the path for a major difference in the way we treat tumors that are resistant or recurring. Genetically altered T cells used to produce tumor-specific chimeric antigen receptors are resurrected field of adoptive cell therapy by demonstrating remarkable success in the treatment of malignant tumors. Because of the molecular complexity of chimeric antigen receptors -T cells, a variety of engineering approaches to improve safety and effectiveness are necessary to realize larger therapeutic uses. In this study, we investigate at new strategies for enhancing chimeric antigen receptors-T cell therapy by altering chimeric antigen receptors proteins, T lymphocytes, and their relations with other solid tumor microenvironment (TME) aspects.

Keywords

chimeric antigen receptors-T cell; solid tumor microenvironment; cancer therapy

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