What We Know About Kininogen Structure – Importance for Function and Perspectives from Cryo-EM

Michal Błażej Ponczek

doi:10.20944/preprints202110.0342.v1

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preprints.org > biology and life sciences > biochemistry and molecular biology > doi: 10.20944/preprints202110.0342.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

What We Know About Kininogen Structure – Importance for Function and Perspectives from Cryo-EM

Michal Błażej Ponczek

Version 1 : Received: 22 October 2021 / Approved: 25 October 2021 / Online: 25 October 2021 (10:49:23 CEST)
Version 2 : Received: 30 October 2021 / Approved: 1 November 2021 / Online: 1 November 2021 (13:50:19 CET)

A peer-reviewed article of this Preprint also exists.

Ponczek, M.B. High Molecular Weight Kininogen: A Review of the Structural Literature. Int. J. Mol. Sci. 2021, 22, 13370. Ponczek, M.B. High Molecular Weight Kininogen: A Review of the Structural Literature. Int. J. Mol. Sci. 2021, 22, 13370.

Abstract

Kininogens are multidomain glycoproteins found in the blood of most vertebrates. They are important in the blood coagulation cascade pathways - in intrinsic pathway activation leading to thrombin generation partially independently from tissue factor dependent extrinsic pathway, connecting blood coagulation with the kallikrein-kinin system. Nothing is known about the shape on atomic level therefore the endeavor to obtain the good-quality spatial structure of kininogens is important for a better understanding of their role in disease and treatment. Application of cryo-EM is important for solving the spatial structure of kininogens, drawing new frontiers in understanding the function and opening new pathways for drug development.

Keywords

kininogen; structure; AlphaFold; cryo-EM; proteins; kinin; bradykinin

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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