What We Know About Kininogen Structure – Importance for Function and Perspectives from Cryo-EM

Michal Błażej Ponczek

doi:10.20944/preprints202110.0342.v1

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preprints.org > life sciences > biochemistry > doi: 10.20944/preprints202110.0342.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

What We Know About Kininogen Structure – Importance for Function and Perspectives from Cryo-EM

Michal Błażej Ponczek

Version 1 : Received: 22 October 2021 / Approved: 25 October 2021 / Online: 25 October 2021 (10:49:23 CEST)
Version 2 : Received: 30 October 2021 / Approved: 1 November 2021 / Online: 1 November 2021 (13:50:19 CET)

A peer-reviewed article of this Preprint also exists.

Ponczek, M.B. High Molecular Weight Kininogen: A Review of the Structural Literature. Int. J. Mol. Sci. 2021, 22, 13370. Ponczek, M.B. High Molecular Weight Kininogen: A Review of the Structural Literature. Int. J. Mol. Sci. 2021, 22, 13370.

DOI: 10.3390/ijms222413370

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Abstract

Kininogens are multidomain glycoproteins found in the blood of most vertebrates. They are important in the blood coagulation cascade pathways - in intrinsic pathway activation leading to thrombin generation partially independently from tissue factor dependent extrinsic pathway, connecting blood coagulation with the kallikrein-kinin system. Nothing is known about the shape on atomic level therefore the endeavor to obtain the good-quality spatial structure of kininogens is important for a better understanding of their role in disease and treatment. Application of cryo-EM is important for solving the spatial structure of kininogens, drawing new frontiers in understanding the function and opening new pathways for drug development.

Keywords

kininogen; structure; AlphaFold; cryo-EM; proteins; kinin; bradykinin

Subject

LIFE SCIENCES, Biochemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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