Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Biome Profiling and Clinical Parasitology: Tools for Gut Microbiota Restoring

Version 1 : Received: 9 October 2021 / Approved: 11 October 2021 / Online: 11 October 2021 (14:20:22 CEST)

How to cite: pane, S.; Ristori, M.V.; gardini, S.; russo, A.; Del Chierico, F.; PUTIGNANI, L. Biome Profiling and Clinical Parasitology: Tools for Gut Microbiota Restoring. Preprints 2021, 2021100167 (doi: 10.20944/preprints202110.0167.v1). pane, S.; Ristori, M.V.; gardini, S.; russo, A.; Del Chierico, F.; PUTIGNANI, L. Biome Profiling and Clinical Parasitology: Tools for Gut Microbiota Restoring. Preprints 2021, 2021100167 (doi: 10.20944/preprints202110.0167.v1).

Abstract

A growing body of evidences is showing that dysbiotic gut microbiota may correlate with a wide range of disorders; hence, the clinical use of microbiota maps and fecal microbiota transplantation (FMT) can be exploited in the clinic of some infectious diseases. Through direct or indirect ecological and functional competition, FMT may stimulate decolonization of pathogens or opportunistic pathogens, modulating immune response and colonic inflammation, and restoring intestinal homeostasis, with reduction of host damage. Herein, we discuss how diagnostic parasitology may contribute to design clinical metagenomics pipelines and FMT programs, especially in pediatric subjects. The consequences of a more specialized diagnostics in the context of gut microbiota communities may improve the clinical parasitology and extend its applications to the prevention and treatment of several communicable and even noncommunicable disorders.

Keywords

parasites; microbiota; faecal microbiota transplantation (FMT)

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