Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Diabetes-associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia

Version 1 : Received: 29 September 2021 / Approved: 30 September 2021 / Online: 30 September 2021 (14:01:44 CEST)

How to cite: Ngo, M.D.; Bartlett, S.; Ronacher, K. Diabetes-associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia. Preprints 2021, 2021090516 (doi: 10.20944/preprints202109.0516.v1). Ngo, M.D.; Bartlett, S.; Ronacher, K. Diabetes-associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia. Preprints 2021, 2021090516 (doi: 10.20944/preprints202109.0516.v1).

Abstract

Diabetes is a major risk factor for tuberculosis (TB). Diabetes increases the risk of progression from latent tuberculosis infection (LTBI) to active pulmonary TB and TB patients with diabetes are at greater risk of more severe disease and adverse TB treatment outcomes compared to TB patients without co-morbidities. Diabetes is a complex disease characterized not only by hyperglycemia but also various forms of dyslipidemia. However, the relative contribution of these underlying metabolic factors to increased susceptibility to TB are poorly understood. This review summarizes our current knowledge on epidemiology and clinical manifestation of TB and diabetes comorbidity. We subsequently dissect the relative contribution of body mass index, hyperglycemia, elevated cholesterol and triglycerides on TB disease severity and treatment outcomes. Lastly, we discuss the impact of selected glucose and cholesterol lowering treatments frequently used in the management of diabetes on TB treatment outcomes.

Keywords

Tuberculosis; Mycobacterium tuberculosis; diabetes; hyperglycemia; dyslipidemia; cholesterol; triglycerides

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