Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Prevalence of Multidrug Resistance Mycobacterium Tuberculosis (MDR-TB) Using GeneXpert Assay in Northern Sudan, How Serious is the Situation?

Version 1 : Received: 15 September 2021 / Approved: 17 September 2021 / Online: 17 September 2021 (12:41:23 CEST)

How to cite: Noor, S.K.; Elamin, M.O.; Mahmoud, Z.I.; Salah, M.; Anwar, T.; Osman, A.A.; Natto, H.A. Prevalence of Multidrug Resistance Mycobacterium Tuberculosis (MDR-TB) Using GeneXpert Assay in Northern Sudan, How Serious is the Situation?. Preprints 2021, 2021090314 (doi: 10.20944/preprints202109.0314.v1). Noor, S.K.; Elamin, M.O.; Mahmoud, Z.I.; Salah, M.; Anwar, T.; Osman, A.A.; Natto, H.A. Prevalence of Multidrug Resistance Mycobacterium Tuberculosis (MDR-TB) Using GeneXpert Assay in Northern Sudan, How Serious is the Situation?. Preprints 2021, 2021090314 (doi: 10.20944/preprints202109.0314.v1).

Abstract

Background: World Health Organization (WHO) estimates that there were 558000 new cases with resistance to Rifampicin, of which 82% had multidrug-resistant tuberculosis (MDR-TB). Objectives: We aimed to identify the prevalence of MDR-TB in River Nile state, Sudan, and the risk factors contributing to its occurrence. Methods: This was a descriptive cross-sectional hospital-based study involved 200 specimens taken from patients suspected of having MDR-TB tested using an automated GeneXpert assay. Results: Results of GeneXpert assay showed that the presence of Mycobacterium tuberculosis in 81 (40.5%), and out of 81 positive test results there were 13 (16%) had MDR-TB. Additionally, 7 cases of MDR-TB were previously treated which represented about (53%) of MDR patients, the remaining 6 MDR-TB patients were new cases and represented (47%) of MDR-TB patients. Moreover, there were 4 MDR-TB patients who had a history of contact with MDR-TB patients. Conclusion: Prevalence of MDR-TB in River Nile State, Sudan was 16%, which is greater than WHO estimation for Sudan (10.1%). The results revealed that the main risk factor to develop MDR-TB was a history of contact with MDR-TB, so adherence to treatment and social awareness about the spread of MDR-TB are crucial preventive measures.

Keywords

GeneXpert; MDR-TB; Prevalence; River Nile State; Sudan

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