Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Schizophrenia and Hospital Admissions for Cardiovascular Events in a Large Population. The APNA Study.

Sara Guillen-Aguinaga
ORCID logo ,
Antonio Brugos-Larumbe
,
Laura Guillen-Aguinaga
ORCID logo ,
Felipe Ortuño
,
Francisco Guillen-Grima
* ORCID logo ,
Luis Forga
ORCID logo ,
Ines Aguinaga-Ontoso
ORCID logo
Version 1 : Received: 14 September 2021 / Approved: 15 September 2021 / Online: 15 September 2021 (11:35:44 CEST)
Version 2 : Received: 28 December 2021 / Approved: 30 December 2021 / Online: 30 December 2021 (19:42:41 CET)

A peer-reviewed article of this Preprint also exists.

Guillen-Aguinaga, S.; Brugos-Larumbe, A.; Guillen-Aguinaga, L.; Ortuño, F.; Guillen-Grima, F.; Forga, L.; Aguinaga-Ontoso, I. Schizophrenia and Hospital Admissions for Cardiovascular Events in a Large Population: The APNA Study. J. Cardiovasc. Dev. Dis. 2022, 9, 25. https://doi.org/10.3390/jcdd9010025 Guillen-Aguinaga, S.; Brugos-Larumbe, A.; Guillen-Aguinaga, L.; Ortuño, F.; Guillen-Grima, F.; Forga, L.; Aguinaga-Ontoso, I. Schizophrenia and Hospital Admissions for Cardiovascular Events in a Large Population: The APNA Study. J. Cardiovasc. Dev. Dis. 2022, 9, 25. https://doi.org/10.3390/jcdd9010025

Abstract

(1) Background: Patients with schizophrenia have higher mortality, with cardiovascular diseases being the first cause of mortality. This study aims to estimate the excess risk of hospital admission for cardiovascular events in schizophrenic patients, adjusting for comorbidity and risk factors. (2) Methods: The APNA study is a dynamic prospective cohort of all residents in Navarra, Spain. 505889 people over 18 years were followed during 5 years. The endpoint was hospital admissions for a cardiovascular event. Direct Acyclic Graphs (DAG) and Cox regression were used. (3) Results: Schizophrenic patients had an HR 1.414 (1.031-1.938) of hospital admission for a cardiovascular event after adjusting for age, sex, hypertension, type 2 diabetes, dyslipidemia, smoking, low income, obesity, Charlson Index, antecedents of cardiovascular disease, and smoking. (4) Conclusions: Patients with schizophrenia have a higher risk of hospital admission for cardiovascular events than persons with the same risk factors without schizophrenia. Primary care nursing interventions should be implemented to monitor these patients and reduce cardiovascular risk factors.

Keywords

Cardiovascular; Schizophrenia; Prospective Cohort; hospital admissions.

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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