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Adp-Ribosylation as Post-Translational Modification of Proteins: Use of Inhibitors in Cancer Control

This version is not peer-reviewed.

Submitted:

12 September 2021

Posted:

13 September 2021

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Abstract
Among post-translational modifications of proteins, ADP-ribosylation has been studied for over fifty years, assigning to this PTM a large set of functions, including DNA repair, transcription and cell signaling. This review presents an update on the function of a large set of enzyme writers, the readers that are recruited by the modified targets, and the erasers that reverse the modification to the original amino acid residue, removing the covalent bonds formed. In particular, the review provides details on the involvement of the enzymes performing MAR/PAR cycling in cancers. Of note, there is potential for application of the inhibitors developed for cancer also in the therapy of non-oncological diseases such as the protection against oxidative stress, suppression of inflammatory responses, and the treatment of neurodegenerative diseases. This field of studies is not concluded, since novel enzymes are being discovered at a rapid pace.
Keywords: 
ADP-ribosyl transferase (ART); Poly ADP-ribose polymerase (PARP); ADP-ribose (ADPR); Sirtuin (SIRT); poly ADP-ribose glycohydrolase (PARG); ADP-ribose hydrolase (ARH); Macro-domain (MACRO).
Subject: 
Biology and Life Sciences  -   Biochemistry and Molecular Biology
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.

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