Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Role of Extracellular Vesicles in Cell Death and Inflammation

Version 1 : Received: 9 September 2021 / Approved: 9 September 2021 / Online: 9 September 2021 (10:31:49 CEST)

A peer-reviewed article of this Preprint also exists.

Sanwlani, R.; Gangoda, L. Role of Extracellular Vesicles in Cell Death and Inflammation. Cells 2021, 10, 2663. Sanwlani, R.; Gangoda, L. Role of Extracellular Vesicles in Cell Death and Inflammation. Cells 2021, 10, 2663.

Journal reference: Cells 2021, 10, 2663
DOI: 10.3390/cells10102663

Abstract

Extracellular vesicles (EVs) have been identified as novel mediators of intercellular communication. They work via delivering the sequestered cargo to cells in close vicinity as well as distant sites in the body, regulating pathophysiological processes. Cell death and inflammation are biologically crucial processes in both normal physiology and pathology. These processes are indistinguishably linked with their effectors modulating the other process. For instance, during an unresolvable infection, the upregulation of specific immune mediators leads to inflammation causing cell death and tissue damage. EVs have gained considerable interest as mediators of both cell death and inflammation during conditions such as sepsis. This review summarizes the types of extracellular vesicles known to date and their roles in mediating immune responses leading to cell death and inflammation with specific focus on sepsis and lung inflammation.

Keywords

extracellular vesicles; exosomes; microvesicles; apoptotic bodies; apoptotic extracellular vesicles; cell death; inflammation; sepsis; lung inflammatory disorders; SARS-CoV-2

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