Version 1
: Received: 7 September 2021 / Approved: 7 September 2021 / Online: 7 September 2021 (11:49:31 CEST)
Version 2
: Received: 8 June 2022 / Approved: 8 June 2022 / Online: 8 June 2022 (12:29:32 CEST)
How to cite:
Dakkak, Y.; van Dijk, B.; Jansen, F.; Wisse, L.; Reijnierse, M.; van der Helm-van Mil, A.; de Ruiter, M. Evidence for the Presence of Synovial Sheaths Surrounding the Extensor Tendons at the Metacarpophalangeal Joints. Preprints2021, 2021090122. https://doi.org/10.20944/preprints202109.0122.v2
Dakkak, Y.; van Dijk, B.; Jansen, F.; Wisse, L.; Reijnierse, M.; van der Helm-van Mil, A.; de Ruiter, M. Evidence for the Presence of Synovial Sheaths Surrounding the Extensor Tendons at the Metacarpophalangeal Joints. Preprints 2021, 2021090122. https://doi.org/10.20944/preprints202109.0122.v2
Dakkak, Y.; van Dijk, B.; Jansen, F.; Wisse, L.; Reijnierse, M.; van der Helm-van Mil, A.; de Ruiter, M. Evidence for the Presence of Synovial Sheaths Surrounding the Extensor Tendons at the Metacarpophalangeal Joints. Preprints2021, 2021090122. https://doi.org/10.20944/preprints202109.0122.v2
APA Style
Dakkak, Y., van Dijk, B., Jansen, F., Wisse, L., Reijnierse, M., van der Helm-van Mil, A., & de Ruiter, M. (2022). Evidence for the Presence of Synovial Sheaths Surrounding the Extensor Tendons at the Metacarpophalangeal Joints. Preprints. https://doi.org/10.20944/preprints202109.0122.v2
Chicago/Turabian Style
Dakkak, Y., Annette van der Helm-van Mil and Marco de Ruiter. 2022 "Evidence for the Presence of Synovial Sheaths Surrounding the Extensor Tendons at the Metacarpophalangeal Joints" Preprints. https://doi.org/10.20944/preprints202109.0122.v2
Abstract
Background. MRI-detected inflammation around the extensor tendons of metacarpophalangeal (MCP-)joints is prevalent in RA and poses a markedly increased risk of RA-development when present in arthralgia patients. Such inflammation is called ‘peritendinitis’ since anatomy literature reports no presence of a tenosynovial sheath at these tendons. However, the presence or absence of tenosynovium at these extensor tendons has never been studied. Methods. Therefore, an anatomical and histological study of extensor tendons at the MCP-joints of two embalmed human hands was performed. Routine histology with Haematoxylin-Eosin staining and immunohistochemical staining was performed. Results. Immunohistochemistry showed presence of markers for synovial macrophages and fibroblast-like synoviocytes bordering a natural dorsal space next to the extensor tendon, suggesting the presence of a synovial lining. Conclusion. This implies that contrast-enhancement on MRI around extensor tendons at MCP-joints observed in early RA and pre-RA likely represents tenosynovitis and that inflammation of this synovial tissue is an early feature of RA.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
8 June 2022
Commenter:
Bastiaan van Dijk
Commenter's Conflict of Interests:
Author
Comment:
Additional histological analyses using immunohistochemical staining for markers of synovial tissues were performed, providing more robust evidence of the presence of fibroblast-like synoviocytes and macrophages lining the extensor tendon.
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Commenter: Bastiaan van Dijk
Commenter's Conflict of Interests: Author