Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Aphasia After Acute Ischemic Stroke in Romania: Epidemiology and Impact on Tertiary Care Resources

Version 1 : Received: 31 August 2021 / Approved: 2 September 2021 / Online: 2 September 2021 (14:39:03 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: Balneo and PRM Research Journal 2021
DOI: 10.12680/balneo.2021.465


We aimed to reveal the disease burden of aphasia after acute ischemic stroke (AIS) at the national level and investigate the impact of aphasia on tertiary care resources and patient outcomes. The local database from the Cluj-Napoca Emergency County Hospital (CNECH), the second largest stroke center in Romania was used to export demographics, baseline clinical and laboratory data, inpatient length of stay (LOS), NIH Stroke Scale (NIHSS), and discharge modified Rankin Scale (mRS) score data for all AIS patients admitted during March 2019. Of 92 patients included in the study, 30 (32.6 %) had aphasia on admission. In a marginally significant unadjusted hierarchical multiple regression model, individuals with aphasia had a LOS of 1.86 days longer than stroke survivors without aphasia. In an adjusted version of the model, the NIHSS score at baseline was a significant predictor for LOS. In addition, the presence of aphasia was associated with a 1.49 increase in the mean mRS score. Aphasia was a marginally significant predictor for increased LOS. Presence of aphasia was more likely to produce a poor functional outcome. Considering an estimated impact of approximately EUR 3 million on direct medical expenditure annually, future policymaking efforts should improve prevention of stroke and improved access to post-stroke aphasia care in Romania.


aphasia; acute ischemic stroke; length of stay; mRS; NIHSS



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