Working Paper Review Version 1 This version is not peer-reviewed

Obesity – An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances

Version 1 : Received: 30 August 2021 / Approved: 1 September 2021 / Online: 1 September 2021 (17:29:05 CEST)

A peer-reviewed article of this Preprint also exists.

Gjermeni, E.; Kirstein, A.S.; Kolbig, F.; Kirchhof, M.; Bundalian, L.; Katzmann, J.L.; Laufs, U.; Blüher, M.; Garten, A.; Duc, D.L. Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances. Biomolecules 2021, 11, 1426. Gjermeni, E.; Kirstein, A.S.; Kolbig, F.; Kirchhof, M.; Bundalian, L.; Katzmann, J.L.; Laufs, U.; Blüher, M.; Garten, A.; Duc, D.L. Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances. Biomolecules 2021, 11, 1426.

Journal reference: Biomolecules 2021, 11, 1426
DOI: 10.3390/biom11101426

Abstract

Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, an-tagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat absorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including inter-section points to the new generation of antidiabetic drugs. We provide insight into the effective-ness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.

Keywords

obesity; diabetes mellitus; anti-obesity drugs; obesity metabolism; energy balance

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