Ayalur Raghu, S.; Ashraf, B.; Jolly, M.K. Biophysical and Biochemical Attributes of Hybrid Epithelial/Mesenchymal Phenotypes. Preprints2021, 2021080453. https://doi.org/10.20944/preprints202108.0453.v1
APA Style
Ayalur Raghu, S., Ashraf, B., & Jolly, M.K. (2021). Biophysical and Biochemical Attributes of Hybrid Epithelial/Mesenchymal Phenotypes. Preprints. https://doi.org/10.20944/preprints202108.0453.v1
Chicago/Turabian Style
Ayalur Raghu, S., Bazella Ashraf and Mohit Kumar Jolly. 2021 "Biophysical and Biochemical Attributes of Hybrid Epithelial/Mesenchymal Phenotypes" Preprints. https://doi.org/10.20944/preprints202108.0453.v1
Abstract
The Epithelial- Mesenchymal Transition (EMT) is a biological phenomenon associated with explicit phenotypic and molecular changes in cellular traits. Unlike the earlier-held popular belief of it being a binary process, EMT is now thought of as a landscape including diverse hybrid E/M phenotypes manifested by varying degrees of the transition. These hybrid cells can co-express both epithelial and mesenchymal markers and/or functional traits, and can possess the property of collective cell migration, enhanced tumor-initiating ability, and immune/targeted therapy-evasive features, all of which are often associated with worse patient outcomes. These characteristics of the hybrid E/M cells have led to a surge in studies that map their biophysical and biochemical hallmarks that can be helpful in exploiting their therapeutic vulnerabilities. This review discusses recent advances made in investigating hybrid E/M phenotype(s) from diverse biophysical and biochemical aspects by integrating live cell-imaging, cellular morphology quantification and mathematical modeling, and highlights a set of questions that remain unanswered about the dynamics of hybrid E/M states.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
