Working Paper Article Version 1 This version is not peer-reviewed

‘Energy-dense, High-SFA and Low-Fiber’ Dietary Pattern Lowered Adiponectin But Not Leptin Concentration of Breast Cancer Survivors

Version 1 : Received: 19 August 2021 / Approved: 20 August 2021 / Online: 20 August 2021 (15:30:06 CEST)

A peer-reviewed article of this Preprint also exists.

Shahril, M.R.; Zakarai, N.S.; Appannah, G.; Nurnazahiah, A.; Mohamed, H.J.J.; Ahmad, A.; Lua, P.L.; Fenech, M. ‘Energy-Dense, High-SFA and Low-Fiber’ Dietary Pattern Lowered Adiponectin but Not Leptin Concentration of Breast Cancer Survivors. Nutrients 2021, 13, 3339. Shahril, M.R.; Zakarai, N.S.; Appannah, G.; Nurnazahiah, A.; Mohamed, H.J.J.; Ahmad, A.; Lua, P.L.; Fenech, M. ‘Energy-Dense, High-SFA and Low-Fiber’ Dietary Pattern Lowered Adiponectin but Not Leptin Concentration of Breast Cancer Survivors. Nutrients 2021, 13, 3339.

Journal reference: Nutrients 2021, 13, 3339
DOI: 10.3390/nu13103339

Abstract

Dietary pattern (DP) and its relationship with disease biomarkers has received recognition in nutritional epidemiology investigations. However, DP relationships with adipokines (i.e., adiponectin and leptin) among breast cancer survivors remain unclear. Therefore, we assessed relationships between DP with high molecular weight (HMW) adiponectin and leptin concentration among breast cancer survivors. This cross-sectional study involved 128 breast cancer survivors who attended the oncology outpatient clinic at two main government hospitals in East Coast of Peninsular Malaysia. The serum concentration of HMW adiponectin and leptin were measured using enzyme-linked immunosorbent assay (ELISA) kits. Reduced rank regression method was used to analyze DP. Relationships between DP with HMW adiponectin and leptin were examined using regression models. Findings showed that a one-unit increase in the ‘energy-dense, high-saturated fat and low-fiber’ DP z-score was associated with a 0.41 µg/mL lower HMW adiponectin (95% CI: -0.806, -0.014) which was independent of age, BMI, cancer stage, duration since diagnosis, education level and occupation status. A similar relationship with leptin concentration was not observed. In conclusion, ‘energy-dense, high-saturated fat and low-fiber’ DP, which is characterized by high sugar-sweetened drink and fat-based spread but low intake of fruits and vegetables, is an unhealthy dietary pattern and unfavorable for HMW adiponectin concentration but not for leptin. These findings could serve as a basis in developing specific preventive strategies that are tailored to the growing population of breast cancer survivors.

Keywords

HMW adiponectin; leptin; dietary patterns; breast cancer survivors

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