Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

In Silico Study of Silybum Marianum Targeting Parp Protein (4UND Protein)

Version 1 : Received: 18 August 2021 / Approved: 18 August 2021 / Online: 18 August 2021 (14:14:01 CEST)

How to cite: Gosavi, H.D.; Badhe, P. In Silico Study of Silybum Marianum Targeting Parp Protein (4UND Protein). Preprints 2021, 2021080384 (doi: 10.20944/preprints202108.0384.v1). Gosavi, H.D.; Badhe, P. In Silico Study of Silybum Marianum Targeting Parp Protein (4UND Protein). Preprints 2021, 2021080384 (doi: 10.20944/preprints202108.0384.v1).

Abstract

Silybum Marianum, is a plant belonging to the family Asteraceae. For many centuries it has been used a natural remedy for many diseases like Liver and Biliary tract diseases. It is effective as an anti-oxidant and is used in a variety of diseases. This study was conducted to check the effects of Silybum Marianum on PARP protein (4UND protein).The Molecular Docking techniques was chosen to check the effects of different chemical constituents of Silybum marianum on DNA damaging protein. For this purpose, different PARP inhibitor drugs were taken as standard. The Molecular Docking of the chemical constituents of Silybum marianum was performed using 4UND protein with the help of PyRx software along with BIOVIA Drug Discovery studio software. The result of molecular docking showed that some of the chemical constituent have higher binding affinity than standard PARP inhibitor drugs.

Keywords

Silybum Marianum; Molecular Docking; Parp Protein; 4UND protein

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