Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Left Cardiac Remodelling assessed by Echocardiography is Associated with Rho-kinase Activation in Long-distance Runners

Version 1 : Received: 12 August 2021 / Approved: 13 August 2021 / Online: 13 August 2021 (09:23:48 CEST)

A peer-reviewed article of this Preprint also exists.

Contreras-Briceño, F.; Vega, J.; Mandiola, J.; Ocaranza, M.P.; Herrera, S.; Salinas, M.; Fernández, R.; Jalil, J.E.; Lavandero, S.; Chiong, M.; Godoy, P.; Castro, P.F.; Sitges, M.; Gabrielli, L. Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners. J. Cardiovasc. Dev. Dis. 2021, 8, 118. Contreras-Briceño, F.; Vega, J.; Mandiola, J.; Ocaranza, M.P.; Herrera, S.; Salinas, M.; Fernández, R.; Jalil, J.E.; Lavandero, S.; Chiong, M.; Godoy, P.; Castro, P.F.; Sitges, M.; Gabrielli, L. Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners. J. Cardiovasc. Dev. Dis. 2021, 8, 118.

Journal reference: J. Cardiovasc. Dev. Dis. 2021, 8, 118
DOI: 10.3390/jcdd8100118

Abstract

This single-blind and cross-sectional study evaluated the role of Rho-kinase (ROCK) as a biomarker of the cardiovascular remodelling process assessed by echocardiography in competitive long-distance runners (LDR) during the training period before a marathon race. Thirty-six healthy male LDR (37.0±5.3 years; 174.0±7.0 height; BMI: 23.8±2.8; VO2-peak: 56.5±7.3 mL·kg-1·min-1) were separated into two groups according to previous training level: high-training (HT, n=16) ≥100 km·week-1 and low-training (LT, n=20) ≥70 and <100 km·week-1. Also, twenty-one healthy nonactive subjects were included as a control group (CTR). A transthoracic echocardiography was performed and ROCK activity levels in circulating leukocytes were measured at rest (48-hr without exercising) the week before the race. HT group showed higher left ventricular mass index (LVMi) and left atrial volume index (LAVi) than other groups (p<0.05, for both), also higher levels of ROCK activity were found in LDR (HT=6.17±1.41 vs CTR=1.64±0.66 (p<0.01); vs LT=2.74±0.84; (p<0.05)). In LDR a direct correlation between ROCK activity levels and LVMi (r=0.83; p<0.001), and LAVi (r=0.70; p<0.001) were found. In conclusion, in male competitive long-distance runners, the load of exercise implicated in marathon training is associated with ROCK activity levels and the left cardiac remodelling process assessed by echocardiography.

Keywords

Athlete´s heart; Cardiac biomarkers; Echocardiography; Exercise; Functional cardiac capacity.

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