Contreras-Briceño, F.; Vega, J.; Mandiola, J.; Ocaranza, M.P.; Herrera, S.; Salinas, M.; Fernández, R.; Jalil, J.E.; Lavandero, S.; Chiong, M.; Godoy, P.; Castro, P.F.; Sitges, M.; Gabrielli, L. Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners. J. Cardiovasc. Dev. Dis.2021, 8, 118.
Contreras-Briceño, F.; Vega, J.; Mandiola, J.; Ocaranza, M.P.; Herrera, S.; Salinas, M.; Fernández, R.; Jalil, J.E.; Lavandero, S.; Chiong, M.; Godoy, P.; Castro, P.F.; Sitges, M.; Gabrielli, L. Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners. J. Cardiovasc. Dev. Dis. 2021, 8, 118.
Contreras-Briceño, F.; Vega, J.; Mandiola, J.; Ocaranza, M.P.; Herrera, S.; Salinas, M.; Fernández, R.; Jalil, J.E.; Lavandero, S.; Chiong, M.; Godoy, P.; Castro, P.F.; Sitges, M.; Gabrielli, L. Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners. J. Cardiovasc. Dev. Dis.2021, 8, 118.
Contreras-Briceño, F.; Vega, J.; Mandiola, J.; Ocaranza, M.P.; Herrera, S.; Salinas, M.; Fernández, R.; Jalil, J.E.; Lavandero, S.; Chiong, M.; Godoy, P.; Castro, P.F.; Sitges, M.; Gabrielli, L. Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners. J. Cardiovasc. Dev. Dis. 2021, 8, 118.
Abstract
This single-blind and cross-sectional study evaluated the role of Rho-kinase (ROCK) as a biomarker of the cardiovascular remodelling process assessed by echocardiography in competitive long-distance runners (LDR) during the training period before a marathon race. Thirty-six healthy male LDR (37.0±5.3 years; 174.0±7.0 height; BMI: 23.8±2.8; VO2-peak: 56.5±7.3 mL·kg-1·min-1) were separated into two groups according to previous training level: high-training (HT, n=16) ≥100 km·week-1 and low-training (LT, n=20) ≥70 and <100 km·week-1. Also, twenty-one healthy nonactive subjects were included as a control group (CTR). A transthoracic echocardiography was performed and ROCK activity levels in circulating leukocytes were measured at rest (48-hr without exercising) the week before the race. HT group showed higher left ventricular mass index (LVMi) and left atrial volume index (LAVi) than other groups (p<0.05, for both), also higher levels of ROCK activity were found in LDR (HT=6.17±1.41 vs CTR=1.64±0.66 (p<0.01); vs LT=2.74±0.84; (p<0.05)). In LDR a direct correlation between ROCK activity levels and LVMi (r=0.83; p<0.001), and LAVi (r=0.70; p<0.001) were found. In conclusion, in male competitive long-distance runners, the load of exercise implicated in marathon training is associated with ROCK activity levels and the left cardiac remodelling process assessed by echocardiography.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
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