Working Paper Article Version 1 This version is not peer-reviewed

Membrane Theory Prediction Is Fully Against Experimental Facts

Version 1 : Received: 11 August 2021 / Approved: 13 August 2021 / Online: 13 August 2021 (08:53:04 CEST)

How to cite: Tamagawa, H.; Delalande, B. Membrane Theory Prediction Is Fully Against Experimental Facts. Preprints 2021, 2021080293 Tamagawa, H.; Delalande, B. Membrane Theory Prediction Is Fully Against Experimental Facts. Preprints 2021, 2021080293

Abstract

Accurate prediction of the membrane potential by membrane theory is possible on the basis that the plasma membrane is selectively permeable to ions and that permeability determines the characteristics of the membrane potential. However, an experimental and artificial cell system with an impermeable membrane serving as a model plasma membrane has a non-zero membrane potential, and this potential generated across the membrane is somehow consistent with the potential characteristics predicted by the membrane theory, despite the impermeability of the membrane to ions. A long-forgotten theory, called the association-induction hypothesis (AIH), has emerged as a more plausible mechanism for generating the membrane potential than the membrane theory to explain this unexpected behavior. The AIH asserts that ion-selective membrane permeability is not necessary for the generation of the membrane potential, which is contrary to the membrane theory. Although such an idea is not easy to accept, the experimental results clearly suggest the correctness of the AIH.

Keywords

membrane theory; Association-Induction Hypothesis; ion transport, ion adsorption; membrane potential

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