Version 1
: Received: 11 August 2021 / Approved: 12 August 2021 / Online: 12 August 2021 (08:46:55 CEST)
How to cite:
Usharauli, D.; Kamala, T. Pathological T Helper Polarization Requires Pre-existing Cross-Reactive Memory T Cells. Preprints2021, 2021080270. https://doi.org/10.20944/preprints202108.0270.v1
Usharauli, D.; Kamala, T. Pathological T Helper Polarization Requires Pre-existing Cross-Reactive Memory T Cells. Preprints 2021, 2021080270. https://doi.org/10.20944/preprints202108.0270.v1
Usharauli, D.; Kamala, T. Pathological T Helper Polarization Requires Pre-existing Cross-Reactive Memory T Cells. Preprints2021, 2021080270. https://doi.org/10.20944/preprints202108.0270.v1
APA Style
Usharauli, D., & Kamala, T. (2021). Pathological T Helper Polarization Requires Pre-existing Cross-Reactive Memory T Cells. Preprints. https://doi.org/10.20944/preprints202108.0270.v1
Chicago/Turabian Style
Usharauli, D. and Tirumalai Kamala. 2021 "Pathological T Helper Polarization Requires Pre-existing Cross-Reactive Memory T Cells" Preprints. https://doi.org/10.20944/preprints202108.0270.v1
Abstract
Naive CD4+ T cells engage cognate peptide MHC-II complexes (pMHC-IIs) to differentiate and acquire one of several T helper (Th) fates whose specific trajectories are guided by a dynamic cytokine milieu that develops in response to antigenic entity. This physiological process is often erroneously conflated with a pathological one termed Th polarization. Using the SPIRAL model, we argue here that unlike Th fate choice, innate signaling alone is insufficient to initiate Th polarization in naive CD4+ T cells, that it instead develops from pre-existing memory CD4+ T cells that express cross-reactive TCRs, and that it inevitably leads to immunopathology.
Keywords
T helper differentiation; T helper polarization; Cross-reactivity; Regulatory T cells; Microbiota; Original Antigenic Sin
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
