Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Influence of Modified Experimental Dental Resin Composites on the Initial In Situ Biofilm – A Triple-Blinded Randomized Controlled Split-Mouth Trial

Version 1 : Received: 6 August 2021 / Approved: 9 August 2021 / Online: 9 August 2021 (07:53:57 CEST)

A peer-reviewed article of this Preprint also exists.

Burgard, N.; Kienitz, M.; Jourdan, C.; Rüttermann, S. The Influence of Modified Experimental Dental Resin Composites on the Initial in Situ Biofilm—A Triple-Blinded, Randomized, Controlled Split-Mouth Trial. Polymers 2021, 13, 2814. Burgard, N.; Kienitz, M.; Jourdan, C.; Rüttermann, S. The Influence of Modified Experimental Dental Resin Composites on the Initial in Situ Biofilm—A Triple-Blinded, Randomized, Controlled Split-Mouth Trial. Polymers 2021, 13, 2814.

Journal reference: Polymers 2021, 13, 2814
DOI: 10.3390/polym13162814

Abstract

The purpose of the study was to investigate the bacterial viability of the initial biofilm on the surface of experimental modified dental resin composites. Twenty-five healthy individuals with good oral hygiene were included in this study. In a split-mouth design, they received acrylic splints with five experimental composite resin specimens. Four of them were modified with either a novel polymeric hollow beads delivery system or methacrylated polymerizable Irgasan (Antibacterial B), while one specimen served as unmodified control (ST). The delivery system based on Poly-Pore® was loaded with one of the active agents Tego® Protect 5000 (Antiadhesive A), Dimethicone (Antiadhesive B) or Irgasan (Antibacterial A). All study subjects refrained from toothbrushing during the study period. Specimens were detached from the splints after 8h and given a live/dead staining before fluorescence microscopy. Friedman test and post-hoc Nemenyi test were applied with significance level at p < 0.05. In summary all materials but Antibacterial B showed a significant antibacterial effect compared to ST. In conclusion dental resin composites with Poly-Pore loaded active agents show antibacterial effectiveness in situ.

Keywords

Antibacterial composites; Antiadhesive composites; Poly-Pore; Split-mouth; Clinical trial; Live/dead staining; Bacterial viability

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