Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease

Maria del Carmen Moleon
,
Estrella Martinez-Gomez
ORCID logo ,
Marisa Flook
,
Andreina Peralta-Leal
,
Juan Antonio Gallego
,
Hortensia Sanchez-Gomez
,
Maria Alharilla Montilla
,
Emilio Dominguez
,
Andres Soto-Varela
,
Ismael Aran
,
Lidia Frejo
,
Jose Antonio A. Lopez-Escamez
*
Version 1 : Received: 5 August 2021 / Approved: 6 August 2021 / Online: 6 August 2021 (12:29:43 CEST)

A peer-reviewed article of this Preprint also exists.

Moleon, M.-D.-C.; Martinez-Gomez, E.; Flook, M.; Peralta-Leal, A.; Gallego, J.A.; Sanchez-Gomez, H.; Montilla-Ibañez, M.A.; Dominguez-Durán, E.; Soto-Varela, A.; Aran, I.; Frejo, L.; Lopez-Escamez, J.A. Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease. J. Clin. Med. 2021, 10, 4052. Moleon, M.-D.-C.; Martinez-Gomez, E.; Flook, M.; Peralta-Leal, A.; Gallego, J.A.; Sanchez-Gomez, H.; Montilla-Ibañez, M.A.; Dominguez-Durán, E.; Soto-Varela, A.; Aran, I.; Frejo, L.; Lopez-Escamez, J.A. Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease. J. Clin. Med. 2021, 10, 4052.

Abstract

Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profile in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early onset MD (EOMD, <35 years old), and 39 with late onset MD (LOMD, > 50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p=0.004) and a higher prevalence of migraine than LOMD (p=0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3 and CXCL4 were different between patients with MD or migraine and controls.

Keywords

vertigo; migraine; cytokines; inflammation; vestibular disorders; hearing loss

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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