Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Genetic and Epigenetic Variations of SARS-Cov-2 and Host Genes and Their Impact in Covid-19 Pandemic

Version 1 : Received: 1 August 2021 / Approved: 2 August 2021 / Online: 2 August 2021 (16:17:24 CEST)

How to cite: Meethal, M.E.; Naseef, P.P.; Kuruniyan, M.S.; Abdulla, M.C.; Ollakkod, S.; Ebrahim, S.; Varma, G.G. Genetic and Epigenetic Variations of SARS-Cov-2 and Host Genes and Their Impact in Covid-19 Pandemic. Preprints 2021, 2021080058 (doi: 10.20944/preprints202108.0058.v1). Meethal, M.E.; Naseef, P.P.; Kuruniyan, M.S.; Abdulla, M.C.; Ollakkod, S.; Ebrahim, S.; Varma, G.G. Genetic and Epigenetic Variations of SARS-Cov-2 and Host Genes and Their Impact in Covid-19 Pandemic. Preprints 2021, 2021080058 (doi: 10.20944/preprints202108.0058.v1).

Abstract

The global COVID-19 pandemic claiming global spread continues to evolve, now to the verge of a third wave of outbreak possibly caused by the novel variants of concern of severe acute respiratory syndrome corona virus-2 (SARS-CoV-2). The test positivity rate (TPR) and case fatal-ity rate (CFR) have increased steeply in the second wave of COVID-19 compared to the first. From the example of Kerala, a state in southern India, positivity increased from 1.33% at the peak of wave one in 10th June 2020 to 13.45% during 10th June 2021 in the second wave of pandemic. SARS-CoV-2 is an enveloped single-stranded RNA virus. Angiotensin-Converting Enzyme-2 (ACE-2) is a trans membrane surface protein present on multiple types of cells in the human body to which the viral spike protein attaches. Genetic variations in the SARS-CoV-2 and ACE2 receptor can affect the transmission, clinical manifestations, mortality and the efficacy of drugs and vaccines for COVID-19. Mutations are the primary cause of genetic variations. Given the high TPR and CFR, it is necessary to understand the variations of SARS-CoV-2 and cellular receptors of SARS-CoV-2 at the molecular level. In this review, we summarize the impact of genetic and ep-igenetic variations in determining COVID-19 pathogenesis and disease outcome.

Keywords

SARS-CoV-2; COVID-19; Phylogenetic analysis; Next generation sequence analysis; Virus-Host interaction; Immunology; Antiviral agents; Vaccine; Virus diagnosis

Subject

LIFE SCIENCES, Molecular Biology

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