Version 1
: Received: 1 August 2021 / Approved: 2 August 2021 / Online: 2 August 2021 (16:17:24 CEST)
How to cite:
Meethal, M. E.; Naseef, P. P.; Kuruniyan, M. S.; Abdulla, M. C.; Ollakkod, S.; Ebrahim, S.; Varma, G. G. Genetic and Epigenetic Variations of SARS-Cov-2 and Host Genes and Their Impact in Covid-19 Pandemic. Preprints2021, 2021080058. https://doi.org/10.20944/preprints202108.0058.v1
Meethal, M. E.; Naseef, P. P.; Kuruniyan, M. S.; Abdulla, M. C.; Ollakkod, S.; Ebrahim, S.; Varma, G. G. Genetic and Epigenetic Variations of SARS-Cov-2 and Host Genes and Their Impact in Covid-19 Pandemic. Preprints 2021, 2021080058. https://doi.org/10.20944/preprints202108.0058.v1
Meethal, M. E.; Naseef, P. P.; Kuruniyan, M. S.; Abdulla, M. C.; Ollakkod, S.; Ebrahim, S.; Varma, G. G. Genetic and Epigenetic Variations of SARS-Cov-2 and Host Genes and Their Impact in Covid-19 Pandemic. Preprints2021, 2021080058. https://doi.org/10.20944/preprints202108.0058.v1
APA Style
Meethal, M. E., Naseef, P. P., Kuruniyan, M. S., Abdulla, M. C., Ollakkod, S., Ebrahim, S., & Varma, G. G. (2021). Genetic and Epigenetic Variations of SARS-Cov-2 and Host Genes and Their Impact in Covid-19 Pandemic. Preprints. https://doi.org/10.20944/preprints202108.0058.v1
Chicago/Turabian Style
Meethal, M. E., Shahul Ebrahim and Godavarma Girish Varma. 2021 "Genetic and Epigenetic Variations of SARS-Cov-2 and Host Genes and Their Impact in Covid-19 Pandemic" Preprints. https://doi.org/10.20944/preprints202108.0058.v1
Abstract
The global COVID-19 pandemic claiming global spread continues to evolve, now to the verge of a third wave of outbreak possibly caused by the novel variants of concern of severe acute respiratory syndrome corona virus-2 (SARS-CoV-2). The test positivity rate (TPR) and case fatal-ity rate (CFR) have increased steeply in the second wave of COVID-19 compared to the first. From the example of Kerala, a state in southern India, positivity increased from 1.33% at the peak of wave one in 10th June 2020 to 13.45% during 10th June 2021 in the second wave of pandemic. SARS-CoV-2 is an enveloped single-stranded RNA virus. Angiotensin-Converting Enzyme-2 (ACE-2) is a trans membrane surface protein present on multiple types of cells in the human body to which the viral spike protein attaches. Genetic variations in the SARS-CoV-2 and ACE2 receptor can affect the transmission, clinical manifestations, mortality and the efficacy of drugs and vaccines for COVID-19. Mutations are the primary cause of genetic variations. Given the high TPR and CFR, it is necessary to understand the variations of SARS-CoV-2 and cellular receptors of SARS-CoV-2 at the molecular level. In this review, we summarize the impact of genetic and ep-igenetic variations in determining COVID-19 pathogenesis and disease outcome.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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