Working Paper Review Version 1 This version is not peer-reviewed

COVID-19 Animal Models and Vaccines: Current Landscape and Future Prospects

Version 1 : Received: 31 July 2021 / Approved: 2 August 2021 / Online: 2 August 2021 (13:15:48 CEST)

How to cite: Wang, S.; Li, L.; Yan, F.; Gao, Y.; Yang, S.; Xia, X. COVID-19 Animal Models and Vaccines: Current Landscape and Future Prospects. Preprints 2021, 2021080042 Wang, S.; Li, L.; Yan, F.; Gao, Y.; Yang, S.; Xia, X. COVID-19 Animal Models and Vaccines: Current Landscape and Future Prospects. Preprints 2021, 2021080042

Abstract

The worldwide pandemic of coronavirus disease 2019 (COVID-19) has become an unprecedented challenge to global public health. With the intensification of the COVID-19 epidemic, the development of vaccines and therapeutic drugs against the etiological agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are also widespread. To prove the effectiveness and safety of these preventive vaccines and therapeutic drugs, available animal models that faithfully recapitulate clinical hallmarks of COVID-19 are urgently needed. Currently, animal models including mice, golden hamsters, ferrets, nonhuman primates and other susceptible animals have been involved in the study of COVID-19. 92 vaccine candidates have entered clinical trials after the primary evaluation in animal models, of which inactivated vaccines, subunit vaccines, virus-vectored vaccines and mRNA vaccines are promising vaccine candidates. In this review, we summarize the landscape of animal models and advanced vaccines with efficacy range from about 50% to more than 95%. In addition, we point out future directions for animal models and vaccine development, aiming at providing valuable information and accelerating the breakthroughs confronting SARS-CoV-2.

Keywords

COVID-19; SARS-CoV-2; animal models; vaccines; future prospects

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