Working Paper Article Version 1 This version is not peer-reviewed

Synchrotron X-Ray Irradiation of a Rat’s Head Model: Monte Carlo Study of Chromatic Gel Dosimetry

Version 1 : Received: 26 July 2021 / Approved: 27 July 2021 / Online: 27 July 2021 (09:23:39 CEST)

A peer-reviewed article of this Preprint also exists.

Peleg Walg, Y.; Krutman, Y.; Berman, A.; Orion, I. Synchrotron X-ray Irradiation of a Rat’s Head Model: Monte Carlo Study of Chromatic Gel Dosimetry. Appl. Sci. 2021, 11, 7389. Peleg Walg, Y.; Krutman, Y.; Berman, A.; Orion, I. Synchrotron X-ray Irradiation of a Rat’s Head Model: Monte Carlo Study of Chromatic Gel Dosimetry. Appl. Sci. 2021, 11, 7389.

Journal reference: Appl. Sci. 2021, 11, 7389
DOI: 10.3390/app11167389

Abstract

Accurate treatment planning in radiotherapy essentially decreases secondary damage to healthy tissue surrounding the tumor. Due to plans to use a direct, highly collimated, narrow beam with high intensity to treat small area tumors, researchers have studied microbeam radiation therapy extensively. Using a synchrotron beam as the radiation source may help to limit secondary damage, but treatment planning using computerized simulations and dosimetry is still necessary to achieve optimal results. For this purpose, PDA-gel dosimeters were developed and their sensitivity around a 150 keV induced synchrotron X-ray radiation beam was examined via Monte Carlo simulations using the EGS5 code system. The microbeam development is now at the animal study stage. In this study, we simulate the irradiation of a rat's brain. The simulation results obtained spectra for two types of PDA-gel dosimeters that were compared with the spectrum obtained in a modelized brain tumor of a rat. Additionally, percentage depth dose curves were calculated for the brain tissue and the two gels. Correction equations for the dosimeters were obtained from the dose-difference plots. For further references, these equations can be used to calculate the actual dose in a brain tumor in a rat. The Monte Carlo simulations demonstrate that PDA-gel dosimeters can be used as a reference technique in planning treatment using synchrotron irradiations and in other medical treatment planning methods.

Keywords

X-ray; Gel dosimeters; EGS5; Monte Carlo simulations; percentage depth dose; polydiacetylene

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