Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Tracking the CAR-T Revolution: Analysis of Clinical Trials of CAR-T and TCR Therapies for the Treatment of Cancer (1997-2020)

Version 1 : Received: 7 July 2021 / Approved: 8 July 2021 / Online: 8 July 2021 (11:04:10 CEST)

A peer-reviewed article of this Preprint also exists.

Ivica, N.A.; Young, C.M. Tracking the CAR-T Revolution: Analysis of Clinical Trials of CAR-T and TCR-T Therapies for the Treatment of Cancer (1997–2020). Healthcare 2021, 9, 1062. Ivica, N.A.; Young, C.M. Tracking the CAR-T Revolution: Analysis of Clinical Trials of CAR-T and TCR-T Therapies for the Treatment of Cancer (1997–2020). Healthcare 2021, 9, 1062.

Journal reference: Healthcare 2021, 9, 1062
DOI: 10.3390/healthcare9081062

Abstract

Chimeric antigen receptor and T-cell receptor (CAR-T/TCR) cellular immunotherapies have shown remarkable success in the treatment of some refractory B-cell malignancies, with potential to provide durable clinical response for other types of cancer. In this paper, we look at all available FDA CAR-T/TCR clinical trials for the treatment of cancer, and analyze them with respect to different disease tissues, targeted antigens, products, and originator locations. We found that 627 of 1,007 registered are currently active and of those 273 (44%) originated in China and 280 (45%) in the US. Our analysis suggests that the rapid increase in the number of clinical trials is driven by the development of different CAR-T products that use a similar therapeutic approach. We coin the term bioparallels to describe such products. Our results suggest that one feature of the CAR-T/TCR industry may be a robust response to success and failure of competitor products.

Keywords

CAR-T; TCR; cancer immunotherapy; immunotherapy clinical trials

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