Working Paper Article Version 1 This version is not peer-reviewed

Intra-Articular Hybrid Hyaluronic Acidinjection Treatment Inknee Osteoarthritis in Overweight Individuals:a Single-Center, Open-Label, Prospective Trial.

Version 1 : Received: 5 July 2021 / Approved: 6 July 2021 / Online: 6 July 2021 (12:46:23 CEST)

A peer-reviewed article of this Preprint also exists.

Scaturro, D.; Vitagliani, F.; Terrana, P.; Cuntrera, D.; Falco, V.; Tomasello, S.; Letizia Mauro, G. Intra-Articular Hybrid Hyaluronic Acid Injection Treatment in Overweight Patients with Knee Osteoarthritis: A Single-Center, Open-Label, Prospective Study. Appl. Sci. 2021, 11, 8711. Scaturro, D.; Vitagliani, F.; Terrana, P.; Cuntrera, D.; Falco, V.; Tomasello, S.; Letizia Mauro, G. Intra-Articular Hybrid Hyaluronic Acid Injection Treatment in Overweight Patients with Knee Osteoarthritis: A Single-Center, Open-Label, Prospective Study. Appl. Sci. 2021, 11, 8711.

Journal reference: Appl. Sci. 2021, 11, 8711
DOI: 10.3390/app11188711

Abstract

(1) Background:A BMI > 25 is the most decisive, albeit modifiable,risk factors for knee osteoarthritis (OA). This study aimed at assessing the efficacy of intra-articular injections of hybrid hyaluronic acid (HA) complexes (Synovial® H-L)for the treatment of kneeOA in overweight patientsin terms ofdisease severity, cardiocirculatory capacity, and quality of life. (2) Materials: In this single-site, open-label, prospective trial, 37 patients with symptomatic knee OA were assessed at baseline and 3 months after ultrasound-guided intra-articular injection of hybrid HA complexes (Synovial® H-L). (3) Results: Primary variables displaying a statistically significant improvement after treatment were pain (NRS), disease severity (WOMAC), and cardiopulmonary capacity a(6-Minute Walk Test). Among secondary variables, quality of life (SF-12) improved significantly, as did analgesic intake for pain control. No statistically significant difference was observed in body fat and muscle mass percentage measured by bioelectrical impedance analysis. (4) Conclusions:Intra-articular hybrid HA injections are significantly effective in improving OA-related disease severity, cardiopulmonary function, and analgesic intake. This supports the role of hybrid HA viscosupplementation as a non-pharmacological treatment to relieve pain, reduce disability and improve quality of life, and limit the risk of polypharmacy in overweight patients with knee OA.

Keywords

Knee osteoarthritis; hybrid hyaluronic acid; viscosupplementation; obesity; overweight.

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