Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Recent Progress of SERS Nanoprobe for pH Detecting and its Application in Biological Imaging

Version 1 : Received: 30 June 2021 / Approved: 1 July 2021 / Online: 1 July 2021 (14:17:48 CEST)

How to cite: Zhang, L.; Zhao, Q.; Jiang, Z.; Shen, J.; Wu, W.; Liu, X.; Fan, Q.; Huang, W. Recent Progress of SERS Nanoprobe for pH Detecting and its Application in Biological Imaging. Preprints 2021, 2021070031 (doi: 10.20944/preprints202107.0031.v1). Zhang, L.; Zhao, Q.; Jiang, Z.; Shen, J.; Wu, W.; Liu, X.; Fan, Q.; Huang, W. Recent Progress of SERS Nanoprobe for pH Detecting and its Application in Biological Imaging. Preprints 2021, 2021070031 (doi: 10.20944/preprints202107.0031.v1).

Abstract

pH value almost affects the function of cells and organisms in all aspects, so in biology, biochemical and many other research fields, it is necessary to apply simple, intuitive, sensitive, stable detection of pH and base characteristics inside and outside the cell. Therefore, many research groups have explored the design and application of pH probes based on surface enhanced Raman scattering(SERS). In this review article, we discussed the basic theoretical background of explaining the working mechanism of pH SERS sensors, and also briefly described the significance of cell pH measurement, and simply classified and summarized the factors that affected the performance of pH SERS probes. Some applications of pH probes based on surface enhanced Raman scattering (SERS) in intracellular and extracellular pH imaging and the combination of other analytical detection techniques are described. And finally, the development prospect of this field is prospected.

Subject Areas

pH; SERS; probe; detection; imaging

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