Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Anti-cancer Immune Reaction and Lymph Node Macrophage; A Review from Human and Animal Studies

Version 1 : Received: 25 June 2021 / Approved: 28 June 2021 / Online: 28 June 2021 (14:27:12 CEST)

A peer-reviewed article of this Preprint also exists.

Komohara, Y.; Anami, T.; Asano, K.; Fujiwara, Y.; Yatsuda, J.; Kamba, T. Anti-Cancer Immune Reaction and Lymph Node Macrophage; A Review from Human and Animal Studies. Immuno 2021, 1, 223-230. Komohara, Y.; Anami, T.; Asano, K.; Fujiwara, Y.; Yatsuda, J.; Kamba, T. Anti-Cancer Immune Reaction and Lymph Node Macrophage; A Review from Human and Animal Studies. Immuno 2021, 1, 223-230.

Journal reference: Immuno 2021, 1, 14
DOI: 10.3390/immuno1030014

Abstract

Lymph nodes are secondary lymphoid organs that appear as bean-like nodules usually <1 cm in size, and they are localized throughout the body. Many antigen-presenting cells such as dendritic cells and macrophages reside in lymph nodes, where they mediate host defense responses against pathogens such as viruses and bacteria. In cancers, antigen-presenting cells induce cytotoxic T lymphocytes (CTLs) to react to cancer cell–derived antigens. Macrophages located in the lymph node sinus are of particular interest in relation to anti-cancer immune responses because many studies using both human specimens and animal models have suggested that lymph node macrophages play a key role in activating anti-cancer CTLs. The regulation of lymph node macrophages therefore represents a potentially promising novel approach in anti-cancer therapy.

Keywords

macrophage; lymph node; CD169; PD-L1

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