Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

PathoBiochemistry-directed Guidelines for COVID-19

Version 1 : Received: 26 June 2021 / Approved: 28 June 2021 / Online: 28 June 2021 (13:49:50 CEST)

How to cite: Buinitskaya, Y.; Wlodaver, C.; Gurinovich, R.; Kastsiuchenka, S. PathoBiochemistry-directed Guidelines for COVID-19. Preprints 2021, 2021060653 (doi: 10.20944/preprints202106.0653.v1). Buinitskaya, Y.; Wlodaver, C.; Gurinovich, R.; Kastsiuchenka, S. PathoBiochemistry-directed Guidelines for COVID-19. Preprints 2021, 2021060653 (doi: 10.20944/preprints202106.0653.v1).

Abstract

Patients with underlying health conditions are at risk for a poor outcome from Coronavirus disease 2019 (COVID-19). Using machine reasoning by the sci.AI system, we investigated the pathobiochemistry of this observation to generate therapeutic guidelines. Facts were extracted and linked from publications available in nlm.nih.gov and Europe PMC to form the dataset which was validated by medical experts. Previously we described how preexisting chronic inflammation renders the acute inflammatory response to Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) excessive translating the SARS-CoV-2 infection into the clinical COVID-19 syndrome. Herein we focus on therapeutic interventions that mitigate the immune response. In essence, from bench to bedside, as depicted in the Graphical Abstract, the clinical management of COVID-19 should aim at: A. Control of excessive oxidant production. B. Neutralization of excessive oxidants. C. Upregulation of nitric oxide (NO) production.

Keywords

COVID-19 therapy, oxidant, antioxidant, nitric oxide (NO), thrombosis

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