PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Metformin Inhibits Esophageal Squamous Cell Carcinoma Viability and Mobility in vitro through Down-regulation of Long Non-coding RNA CCAT1 and SPRY4-IT1
Version 1
: Received: 23 June 2021 / Approved: 25 June 2021 / Online: 25 June 2021 (12:41:51 CEST)
How to cite:
Zhang, M.; Wang, J.; Li, Y.; Qin, L.; Fan, R.; Liu, Y.; Li, W.; Qin, Y.; Lu, P. Metformin Inhibits Esophageal Squamous Cell Carcinoma Viability and Mobility in vitro through Down-regulation of Long Non-coding RNA CCAT1 and SPRY4-IT1. Preprints2021, 2021060624. https://doi.org/10.20944/preprints202106.0624.v1
Zhang, M.; Wang, J.; Li, Y.; Qin, L.; Fan, R.; Liu, Y.; Li, W.; Qin, Y.; Lu, P. Metformin Inhibits Esophageal Squamous Cell Carcinoma Viability and Mobility in vitro through Down-regulation of Long Non-coding RNA CCAT1 and SPRY4-IT1. Preprints 2021, 2021060624. https://doi.org/10.20944/preprints202106.0624.v1
Zhang, M.; Wang, J.; Li, Y.; Qin, L.; Fan, R.; Liu, Y.; Li, W.; Qin, Y.; Lu, P. Metformin Inhibits Esophageal Squamous Cell Carcinoma Viability and Mobility in vitro through Down-regulation of Long Non-coding RNA CCAT1 and SPRY4-IT1. Preprints2021, 2021060624. https://doi.org/10.20944/preprints202106.0624.v1
APA Style
Zhang, M., Wang, J., Li, Y., Qin, L., Fan, R., Liu, Y., Li, W., Qin, Y., & Lu, P. (2021). Metformin Inhibits Esophageal Squamous Cell Carcinoma Viability and Mobility in vitro through Down-regulation of Long Non-coding RNA CCAT1 and SPRY4-IT1. Preprints. https://doi.org/10.20944/preprints202106.0624.v1
Chicago/Turabian Style
Zhang, M., Yongmei Qin and Ping Lu. 2021 "Metformin Inhibits Esophageal Squamous Cell Carcinoma Viability and Mobility in vitro through Down-regulation of Long Non-coding RNA CCAT1 and SPRY4-IT1" Preprints. https://doi.org/10.20944/preprints202106.0624.v1
Abstract
Evidence indicates that the long noncoding RNAs are involved in the metformin-mediated anti-cancer processes. However, the potential effects of the long noncoding RNAs in metformin-mediated anti-tumor processes in esophageal squamous cell carcinomas (ESCC) are still elusive. This study uncovered that metformin decreases the level of long noncoding RNAs CCAT1 and SPRY4-IT1 thereby contributing to the down-regulation of c-Myc and vimentin. Also, the RNA level test of human ESCC tissue confirmed the positive correlation between CCAT1 and c-Myc. These findings demonstrated that metformin facilitated anti-cancer effects by targeting the 2 long noncoding RNAs (CCAT1 and SPRY4-IT1) and their consequential targets c-Myc and vimentin. Therefore, the CCAT1 and SPRY4-IT1 might act as novel molecular targets that mediate the anti-tumor effects in esophageal squamous cell carcinoma. This helps in predicting the treatment response of metformin in patients diagnosed with esophageal squamous cell carcinoma.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
