Koutsifeli, P.; Varma, U.; Daniels, L.; Annandale, M.; Li, X.; Hayes, S.; James, S.; Delbridge, L.; Mellor, K. Evolving Concepts of Glycogen-Selective Autophagy. Preprints2021, 2021060594. https://doi.org/10.20944/preprints202106.0594.v1
APA Style
Koutsifeli, P., Varma, U., Daniels, L., Annandale, M., Li, X., Hayes, S., James, S., Delbridge, L., & Mellor, K. (2021). Evolving Concepts of Glycogen-Selective Autophagy. Preprints. https://doi.org/10.20944/preprints202106.0594.v1
Chicago/Turabian Style
Koutsifeli, P., Lea Delbridge and Kimberley Mellor. 2021 "Evolving Concepts of Glycogen-Selective Autophagy" Preprints. https://doi.org/10.20944/preprints202106.0594.v1
Abstract
Macro-autophagy is an essential cellular process involved in degradation of aberrant organelles and proteins. Initially proposed to be a ‘bulk’ degradation pathway, a more nuanced appreciation of selective autophagy pathways has emerged in recent years. The discovery of a glycogen-selective autophagy pathway (‘glycophagy’) has highlighted the importance of autophagy in regulating cellular metabolic homeostasis and identified a novel non-canonical major pathway of glycogen flux. The field of glycogen autophagy research is at an early evolutionary stage, but already it is clear that the implications of these discoveries are far-reaching and provide scope for multi-disciplinary investigations into the role of glycophagy in health and disease. With potential cognate protein partners identified, the opportunities for targeted intervention have become viable. Here we review the current evidence relating to specific protein mediators involved in glycophagy, and highlight areas of uncertainty that provide opportunity for further investigation.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
