Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Non-Uniform Aspects of SARS-CoV-2 Intraspecies Evolution Reopen Questions on Its Origin

Version 1 : Received: 18 June 2021 / Approved: 18 June 2021 / Online: 18 June 2021 (09:22:08 CEST)

How to cite: Hassan, S.S.; Kodakandla, V.; Redwan, E.M.; Lundstrom, K.; Pal Choudhury, P.; Aroca, Á.S.; Azad, G.K.; Aljabali, A.A.; Palu, G.; Abd El-Aziz, T.M.; Barh, D.; Uhal, B.D.; Adadi, P.; Takayama, K.; Bazan, N.G.; Tambuwala, M.; P. Sherchan, S.; Lal, A.; Chauhan, G.; Baetas-da-Cruz, W.; Uversky, V.N. Non-Uniform Aspects of SARS-CoV-2 Intraspecies Evolution Reopen Questions on Its Origin. Preprints 2021, 2021060472 (doi: 10.20944/preprints202106.0472.v1). Hassan, S.S.; Kodakandla, V.; Redwan, E.M.; Lundstrom, K.; Pal Choudhury, P.; Aroca, Á.S.; Azad, G.K.; Aljabali, A.A.; Palu, G.; Abd El-Aziz, T.M.; Barh, D.; Uhal, B.D.; Adadi, P.; Takayama, K.; Bazan, N.G.; Tambuwala, M.; P. Sherchan, S.; Lal, A.; Chauhan, G.; Baetas-da-Cruz, W.; Uversky, V.N. Non-Uniform Aspects of SARS-CoV-2 Intraspecies Evolution Reopen Questions on Its Origin. Preprints 2021, 2021060472 (doi: 10.20944/preprints202106.0472.v1).

Abstract

Several hypotheses have been presented on the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from its identification as the agent causing the current coronavirus disease 19 (COVID-19) pandemic. So far, no hypothesis has managed to identify the origin, and the issue has resurfaced. Here we have unfolded a pattern of distribution of several mutations in the SARS-CoV-2 proteins across different continents comprising 24 geo-locations. The results showed an evenly uneven distribution of unique protein variants, distinct mutations, unique frequency of common conserved residues, and mutational residues across the 24 geo-locations. Furthermore, ample mutations were identified in the evolutionarily conserved invariant regions in the SARS-CoV-2 proteins across almost all geo-locations we have considered. This pattern of mutations potentially breaches the law of evolutionary conserved functional units of the beta-coronavirus genus. These mutations may lead to several novel SARS-CoV-2 variants with a high degree of transmissibility and virulence. A thorough investigation on the origin and characteristics of SARS-CoV-2 needs to be conducted in the interest of science and to be prepared to meet the challenges of potential future pandemics.

Subject Areas

SARS-CoV-2; Mutations; Furin Cleavage Site (FCS); Evenly-uneven; Invariant regions

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