Version 1
: Received: 14 June 2021 / Approved: 15 June 2021 / Online: 15 June 2021 (08:57:00 CEST)
How to cite:
Ghoneim, A.; Al-Khaldi, A.; Ahmed El-sherif, M.; Elbargisy, R.; Bassiony Ghanem, H.; Zafar, R. Construction, Molecular Docking, Antimicrobial and Antioxidant Activity of Some Novel 3-Substitued Indole Derivatives Using 3-Acetyl Indole. Preprints2021, 2021060387. https://doi.org/10.20944/preprints202106.0387.v1
Ghoneim, A.; Al-Khaldi, A.; Ahmed El-sherif, M.; Elbargisy, R.; Bassiony Ghanem, H.; Zafar, R. Construction, Molecular Docking, Antimicrobial and Antioxidant Activity of Some Novel 3-Substitued Indole Derivatives Using 3-Acetyl Indole. Preprints 2021, 2021060387. https://doi.org/10.20944/preprints202106.0387.v1
Ghoneim, A.; Al-Khaldi, A.; Ahmed El-sherif, M.; Elbargisy, R.; Bassiony Ghanem, H.; Zafar, R. Construction, Molecular Docking, Antimicrobial and Antioxidant Activity of Some Novel 3-Substitued Indole Derivatives Using 3-Acetyl Indole. Preprints2021, 2021060387. https://doi.org/10.20944/preprints202106.0387.v1
APA Style
Ghoneim, A., Al-Khaldi, A., Ahmed El-sherif, M., Elbargisy, R., Bassiony Ghanem, H., & Zafar, R. (2021). Construction, Molecular Docking, Antimicrobial and Antioxidant Activity of Some Novel 3-Substitued Indole Derivatives Using 3-Acetyl Indole. Preprints. https://doi.org/10.20944/preprints202106.0387.v1
Chicago/Turabian Style
Ghoneim, A., Heba Bassiony Ghanem and Rehman Zafar. 2021 "Construction, Molecular Docking, Antimicrobial and Antioxidant Activity of Some Novel 3-Substitued Indole Derivatives Using 3-Acetyl Indole" Preprints. https://doi.org/10.20944/preprints202106.0387.v1
Abstract
This dissertation presents a method for the synthesis of substituted indoles bearing heterocyclic substituents onto the 3- position. The route for the synthesis of the heterocyclic substituents indoles starts from 3-acetyl indole nucleus depend on two parts. One part: Reaction of 3-acetylindole 1 with hydrazide compounds such as phenyl hydrazine, hydrazine hydrate, and thio-semicarbazide, to yield 3-(1-(2-phenylhydrazono) ethyl)-1H-indole 2, 3-(1-hydrazonoethyl)-1H-indole 6, and thiosemicarbazone 10 respectively. 3-(1-Hydrazonoethyl)-1H-indole 6 reacted with thiophene-2-carboxaldeyde, isatin and 3-acetyl indole. In the same way, 3-(1-(2-phenylhydrazono) ethyl)-1H-indole 2 reacted with thioglycollic acid, glycine and benzaldehyde. 3-Acetylindole 1 thiosemicarbazone reacted with acetic anhydride, piperidine, concentration of hydrochloric acid and thiophene-2-carboxaldeyde. Second part. Reaction of 3-acetyl indole 1 with amines compounds such as p-nitroaniline to formed Schiff base 15 which it reacted with thioglycollic acid to give compound 16. 3-Acetyl indole 1 reacted with ethylene diamine to afford bis imine indole to afford compound 17. The reports of this docking study revealed that the new compounds exhibit good antibacterial activity. The synthesized compounds screened in vitro for their antibacterial activity revealed remarkable inhibitory effects against the selected microorganisms. And also an anti-oxidant activity studying for some synthesized compounds. Structures of the newly synthesized compounds examination by spectral data (IR, 1H- NMR and 13C -NMR).
Chemistry and Materials Science, Analytical Chemistry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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