Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Minocycline Derived Silver Nanoparticles for Assessment of Their Antidiabetic Potential against Alloxan induced Diabetic Mice

Syed Akif Raza Kazmi
ORCID logo ,
Muhammad Zahid Qureshi
,
Sadia .
,
Saleh S Alhewairini
,
Shaukat Ali
* ORCID logo ,
Shazia Khurshid
,
Muhammad Saeed
ORCID logo ,
Shumaila Mumtaz
,
Tafail Akbar Mughal
Version 1 : Received: 28 May 2021 / Approved: 1 June 2021 / Online: 1 June 2021 (15:21:02 CEST)

A peer-reviewed article of this Preprint also exists.

Kazmi, S.A.R.; Qureshi, M.Z.; Sadia; Alhewairini, S.S.; Ali, S.; Khurshid, S.; Saeed, M.; Mumtaz, S.; Mughal, T.A. Minocycline-Derived Silver Nanoparticles for Assessment of Their Antidiabetic Potential against Alloxan-Induced Diabetic Mice. Pharmaceutics 2021, 13, 1678. Kazmi, S.A.R.; Qureshi, M.Z.; Sadia; Alhewairini, S.S.; Ali, S.; Khurshid, S.; Saeed, M.; Mumtaz, S.; Mughal, T.A. Minocycline-Derived Silver Nanoparticles for Assessment of Their Antidiabetic Potential against Alloxan-Induced Diabetic Mice. Pharmaceutics 2021, 13, 1678.

DOI: 10.3390/pharmaceutics13101678

Abstract

Diabetes is a life-threatening disease and chronic diabetes affects the parts of the body including the liver, kidney and pancreas. The root cause of diabetes is mainly associated with oxidative stress produced by reactive oxygen species. The minocycline is a polyphenolic drug with excellent antioxidant activities. The objective of the present study was to investigate the antidiabetic potential of minocycline modified silver nanoparticles (Mino/AgNPs) against alloxan-induced diabetic mice. The Mino/AgNPs were synthesized using minocycline as reducing and stabilizing agents. UV-vis, FTIR, X-ray diffraction (XRD) and transmission electron microscopy (TEM) were applied for the characterization of Mino/AgNPs. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay was conducted to determine the antioxidant potential of newly synthesized Mino/AgNPs. The results revealed that the Mino/AgNPs showed higher radical scavenging activity (IC50 = 19.7 µg/mL) as compared to the minocycline (IC50 = 26.0 µg/mL) and ascorbic acid (IC50 = 25.2 µg/mL). Further, the Mino/AgNPs were successfully employed to examine their antidiabetic potential against Alloxan-induced diabetic mice. Hematological results showed that the mice treated with Mino/AgNPs demonstrated a significant decrease in fasting blood glucose level and lipid profile as compared to the diabetic group. The histopathological examination confirmed that the diabetic mice treated with Mino/AgNPs showed significant recovery and revival of histo-morphology of kidney, central vein of liver and islet cells of the pancreas compared to the diabetic mice. Hence Mino/AgNPs have good antidiabetic potential and could be an appropriate nanomedicine to prevent the development of diabetes.

Keywords

Minocycline, Silver Nanoparticles, Tetracycline, Antidiabetic, In Vivo, Nanomedicine

Subject

LIFE SCIENCES, Biochemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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