Khotimchenko, R.; Bryukhovetskiy, I.; Khotimchenko, M.; Khotimchenko, Y. Bioactive Compounds with Antiglioma Activity from Marine Species. Biomedicines2021, 9, 886.
Khotimchenko, R.; Bryukhovetskiy, I.; Khotimchenko, M.; Khotimchenko, Y. Bioactive Compounds with Antiglioma Activity from Marine Species. Biomedicines 2021, 9, 886.
Khotimchenko, R.; Bryukhovetskiy, I.; Khotimchenko, M.; Khotimchenko, Y. Bioactive Compounds with Antiglioma Activity from Marine Species. Biomedicines2021, 9, 886.
Khotimchenko, R.; Bryukhovetskiy, I.; Khotimchenko, M.; Khotimchenko, Y. Bioactive Compounds with Antiglioma Activity from Marine Species. Biomedicines 2021, 9, 886.
Abstract
The search for new chemical compounds with antitumor pharmacological activity is a necessary process for creating more effective drugs for each specific malignancy type. This review presents the outcomes of screening studies of natural compounds with high anti-glioma activity. Despite significant advances in cancer therapy, there are still some tumors currently considered completely incurable including brain gliomas. This review covers the main problems of the glioma chemotherapy including drug resistance, side effects of common anti-glioma drugs, and genetic diversity of brain tumors. The main emphasis is made on the characterization of natural compounds isolated from marine organisms because taxonomic diversity of organisms in seawaters significantly exceeds that of terrestrial species. Thus, we should expect greater chemical diversity of marine compounds and greater likelihood of finding effective molecules with antiglioma activity. The review covers at least 15 classes of organic compounds with their chemical formulas provided as well as semi-inhibitory concentrations, mechanisms of action, and pharmacokinetic profiles. In conclusion, the analysis of the taxonomic diversity of marine species containing bioactives with antiglioma activity is performed noting cytotoxicity indicators and to the tumor cells in comparison with similar indicators of antitumor agents approved for clinical use as antiglioblastoma chemotherapeutics.
Keywords
antitumor activity; natural compounds; glioma multiforme; brain tumors; marine species
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
