Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Effect of Polyphenols Intake on Obesity-induced Maternal Programming

Version 1 : Received: 25 May 2021 / Approved: 25 May 2021 / Online: 25 May 2021 (12:59:07 CEST)

A peer-reviewed article of this Preprint also exists.

Fortunato, I.M.; dos Santos, T.W.; Ferraz, L.F.C.; Santos, J.C.; Ribeiro, M.L. Effect of Polyphenols Intake on Obesity-Induced Maternal Programming. Nutrients 2021, 13, 2390. Fortunato, I.M.; dos Santos, T.W.; Ferraz, L.F.C.; Santos, J.C.; Ribeiro, M.L. Effect of Polyphenols Intake on Obesity-Induced Maternal Programming. Nutrients 2021, 13, 2390.

Journal reference: Nutrients 2021, 13, 2390
DOI: 10.3390/nu13072390

Abstract

Obesity is a complex chronic disease characterized by excess of body fat. It represents a significant public health problem due to the health-related risk factors. There are growing evidences showing that maternal obesity can program the offspring, which influence neonatal phenotype and predispose offspring to a higher prevalence of metabolic disorders such as obesity. This increased risk may also be epigenetically transmitted across generations. Thus, there is an urgent need to find effective reprogramming approaches in order to resume normal fetal development. Polyphenols are bioactive compounds found in fruits and vegetables that exert their anti-obesity effect through its powerful anti-oxidant and anti-inflammatory activities. Polyphenols supplementation has been proven to counteract the deleterious effects of maternal obesity programming on offspring. Indeed, some polyphenols can cross the placenta and protect the fetal predisposition against obesity. The present review summarizes the effects of dietary polyphenols on obesity-induced maternal reprogramming as an offspring anti-obesity approach.

Keywords

Polyphenol; obesity; maternal programming

Subject

LIFE SCIENCES, Biochemistry

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