Biophysical, Biochemical and Biomedical Evaluation of Collagen Hydrolysate in Comparison to Sulfated Glucosamine from Marine Organisms and Lipids of Fish Oil Origin Used as Chondroprotective Food Supplements

How to cite: Eckert, T.; Jährling-Butkus, M.; Louton, H.; Burg-Roderfeld, M.; Zhang, N.; Zhang, R.; Hesse, K.; Petridis, A.K.; Kožár, T.; Steinmeyer, J.; Schauer, R.; Engelhard, P.; Kozarova, A.; Hudson, J.W.; Siebert, H. Biophysical, Biochemical and Biomedical Evaluation of Collagen Hydrolysate in Comparison to Sulfated Glucosamine from Marine Organisms and Lipids of Fish Oil Origin Used as Chondroprotective Food Supplements. Preprints 2021, 2021050588. https://doi.org/10.20944/preprints202105.0588.v1 Eckert, T.; Jährling-Butkus, M.; Louton, H.; Burg-Roderfeld, M.; Zhang, N.; Zhang, R.; Hesse, K.; Petridis, A.K.; Kožár, T.; Steinmeyer, J.; Schauer, R.; Engelhard, P.; Kozarova, A.; Hudson, J.W.; Siebert, H. Biophysical, Biochemical and Biomedical Evaluation of Collagen Hydrolysate in Comparison to Sulfated Glucosamine from Marine Organisms and Lipids of Fish Oil Origin Used as Chondroprotective Food Supplements. Preprints 2021, 2021050588. https://doi.org/10.20944/preprints202105.0588.v1

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MDPI and ACS Style

Eckert, T.; Jährling-Butkus, M.; Louton, H.; Burg-Roderfeld, M.; Zhang, N.; Zhang, R.; Hesse, K.; Petridis, A.K.; Kožár, T.; Steinmeyer, J.; Schauer, R.; Engelhard, P.; Kozarova, A.; Hudson, J.W.; Siebert, H. Biophysical, Biochemical and Biomedical Evaluation of Collagen Hydrolysate in Comparison to Sulfated Glucosamine from Marine Organisms and Lipids of Fish Oil Origin Used as Chondroprotective Food Supplements. Preprints 2021, 2021050588. https://doi.org/10.20944/preprints202105.0588.v1

APA Style

Eckert, T., Jährling-Butkus, M., Louton, H., Burg-Roderfeld, M., Zhang, N., Zhang, R., Hesse, K., Petridis, A.K., Kožár, T., Steinmeyer, J., Schauer, R., Engelhard, P., Kozarova, A., Hudson, J.W., & Siebert, H. (2021). Biophysical, Biochemical and Biomedical Evaluation of Collagen Hydrolysate in Comparison to Sulfated Glucosamine from Marine Organisms and Lipids of Fish Oil Origin Used as Chondroprotective Food Supplements. Preprints. https://doi.org/10.20944/preprints202105.0588.v1

Chicago/Turabian Style

Eckert, T., John W. Hudson and Hans-Christian Siebert. 2021 "Biophysical, Biochemical and Biomedical Evaluation of Collagen Hydrolysate in Comparison to Sulfated Glucosamine from Marine Organisms and Lipids of Fish Oil Origin Used as Chondroprotective Food Supplements" Preprints. https://doi.org/10.20944/preprints202105.0588.v1

Abstract

The bioactivities of collagen-hydrolysates, sulfated glucosamine and a special fatty acid enriched dog-food were tested in a dog patient study as potential therapeutic treatment options in early osteoarthritis. Biophysical, biochemical, cell biological and molecular modeling methods support that these well-defined substances may act as effective nutraceuticals. Importantly, the applied collagen-hydrolysates as well as sulfated glucosamine residues from marine organisms were strongly supported by both an animal model and molecular modeling of intermolecular interactions. Molecular modeling of predicted interaction dynamics were evaluated for the receptor proteins MMP-3 and ADAMTS-5. These proteins play a prominent role in the maintenance of cartilage health as well as innate and adapted immunity. Nutraceuticals data were generated in a veterinary clinical study focusing on mobility and agility. Specifically, key clinical parameters were obtained from blood probes of German shepherd dogs with early osteoarthritis symptoms fed with collagen-hydrolysates or sulfated glucosamines. Collagen-hydrolysate, a chondroprotective food supplement was examined by high resolution NMR experiments. Molecular modeling simulations were used to further characterize the interaction potency of collagen-fragments and glucosamines with protein receptor structures. Potential beneficial effects of collagen-hydrolysates, sulfated glycans (i.e. sulfated glucosamine from crabs and mussels) and lipids, especially, eicosapentaenoic acid (extracted from fish oil) on biochemical and physiological processes are discussed here in the context of human and veterinary medicine.

Keywords

osteoarthritis; collagen-hydrolysate; sulfated N-acetyl glucosamine; sialic acids; eicosapentaenoic acid (EPA); MMP-3; ADAMTS-5

Subject

Chemistry and Materials Science, Analytical Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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