Working PaperReviewVersion 1This version is not peer-reviewed
Nutritional Effects on the Gut Microbiome & the Brain-Gut Axis: Unlocking the Therapeutic and Preventative Potential of Nutrition for Gut Dysbiosis Associated Diseases
Version 1
: Received: 12 May 2021 / Approved: 13 May 2021 / Online: 13 May 2021 (13:30:00 CEST)
How to cite:
Freund, S.; Mochel, J.; Allenspatch, K. Nutritional Effects on the Gut Microbiome & the Brain-Gut Axis: Unlocking the Therapeutic and Preventative Potential of Nutrition for Gut Dysbiosis Associated Diseases. Preprints2021, 2021050299
Freund, S.; Mochel, J.; Allenspatch, K. Nutritional Effects on the Gut Microbiome & the Brain-Gut Axis: Unlocking the Therapeutic and Preventative Potential of Nutrition for Gut Dysbiosis Associated Diseases. Preprints 2021, 2021050299
Cite as:
Freund, S.; Mochel, J.; Allenspatch, K. Nutritional Effects on the Gut Microbiome & the Brain-Gut Axis: Unlocking the Therapeutic and Preventative Potential of Nutrition for Gut Dysbiosis Associated Diseases. Preprints2021, 2021050299
Freund, S.; Mochel, J.; Allenspatch, K. Nutritional Effects on the Gut Microbiome & the Brain-Gut Axis: Unlocking the Therapeutic and Preventative Potential of Nutrition for Gut Dysbiosis Associated Diseases. Preprints 2021, 2021050299
Abstract
Diet plays a pivotal role in the overall health of an individual. Not only does it help carry out and regulate certain physiological functions, but it also can determine the composition of the gut microbiome. While the relative number of microorganisms that make up the gut microbiome vary between individuals and can be dependent on different environmental factors, there is evidence to suggest that composition of the microbiome can correlate with overall health or disease. When the GI microbiome is disturbed or suddenly changes it results in microbiome dysbiosis, a condition that correlates with the presence of certain diseases. Diseases linked to microbiome dysbiosis range from metabolic disorders, inflammatory bowel diseases to disorders of the brain. Many of these diseases are linked to the connection between the brain and the gut, known as the brain-gut axis. This bidirectional communication is important to maintain normal intestinal function, but is also responsible for the GI response to emotions as well as the emotional response to GI disturbances. By exploiting the interaction between microbiome health and nutrition, diet can be used to alleviate disease symptoms, protect against the development of certain conditions, and better maintain overall health. This review will examine the effects of nutrition on the microbiome, diseases linked to disruption of the normal microbiome, and the way that altering the diet can mitigate symptoms or prevent disease.
Keywords
Gut-Brain Axis; Nutrition; Microbiome; SCFA; Gut dysbiosis
Subject
LIFE SCIENCES, Biochemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
